Evidence map›Paper›PMID 23812450›Full record

ArticleObstetrics and gynecology2013

Activity restriction among women with a short cervix.

William A Grobman, Sharon A Gilbert, Jay D Iams, Catherine Y Spong, George Saade, Brian M Mercer, Alan T N Tita, Dwight J Rouse, Yoram Sorokin, Kenneth J Leveno and 5 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03979196 naterminatednot on this mapstarted 2019, after this paper: background citation

Inpatient vs Outpatient Management of Women With Short Cervix: A Randomized Controlled Trial (RCT)

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2019 to 2021Enrolled5ConditionsPreterm Birth, Pregnancy, High RiskArmsInpatient Management, Outpatient Management
NCT06884761 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Routine Activity on the Risk for Preterm Delivery in Women With a Short Cervix. A Randomized Control Trial

TypeinterventionalSponsorWolfson Medical CenterRan2025 to 2027Enrolled100ConditionsCervical ShorteningArmsMaximal Rest
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Prediction of Spontaneous Preterm Birth Among Nulliparous Women With a Short Cervix.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2016
    Trial
  3. Article
  4. Recommending maternal bedrest to improve intrauterine growth is not proven.American journal of obstetrics and gynecology · 2025
    Article
  5. Article
  6. Activity restriction and risk of adverse pregnancy outcomes.American journal of obstetrics & gynecology MFM · 2024
    Article
  7. Article
  8. Article
  9. Physical activity and pregnancy outcomes: an expert review.American journal of obstetrics & gynecology MFM · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Activity in Pregnancy for Patients with a History of Preterm Birth.Clinical medicine insights. Women's health · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

William A GrobmanFrom the Departments of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois, The Ohio State University, Columbus, Ohio, University of Texas Medical Branch, Galveston, Texas, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio, University of Alabama at Birmingham, Birmingham, Alabama, Brown University, Providence, Rhode Island, Wayne State University, Detroit, Michigan, University of Texas Southwestern Medical Center, Dallas, Texas, Oregon Health & Science University, Portland, Oregon, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, University of Pittsburgh, Pittsburgh, Pennsylvania, and Medical University of South Carolina, Charleston, South Carolina; the George Washington University Biostatistics Center, Washington, DC; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
Sharon A Gilbert
Jay D Iams
Catherine Y Spong
George Saade
Brian M Mercer
Alan T N Tita
Dwight J Rouse
Yoram Sorokin
Kenneth J Leveno
Jorge E Tolosa
John M Thorp
Steve N Caritis
J Peter Van Dorsten
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network*

Funding

Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research NetU10HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ · 2009 to 2021
$174.2M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
SARS-CoV-2 Vaccine Pregnancy RegistryU24HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI Rebecca Gersnoviez Clifton · 2021 to 2026
$39.2M
MATERNAL FETAL RESEARCH NETWORK: DATA COORDINATING CTRU01HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI THOM, ELIZABETH ANN · 1998 to 2008
$27.0M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
NICHD Maternal Fetal Medicine Units NetworkU10HD034116 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI CASEY, BRIAN M · 1996 to 2015
$19.3M
NICHD Maternal Fetal Medicine Units NetworkU10HD034208 · NICHD · UNIVERSITY OF UTAH · PI VARNER, MICHAEL W. · 1996 to 2015
$16.6M
NICHD Maternal Fetal Medicine Units NetworkU10HD027869 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TITA, ALAN THEVENET N. · 1991 to 2015
$12.8M
NICHD Maternal Fetal Medicine Units NetworkU10HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2001 to 2015
$12.5M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000150NCRR NIH HHS 5UL1RR025764NCRR NIH HHS M01 RR000080NCRR NIH HHS M01 RR00080NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1 RR025764NICHD NIH HHS HD21410NICHD NIH HHS HD27869NICHD NIH HHS HD27915NICHD NIH HHS HD27917NICHD NIH HHS HD34116NICHD NIH HHS HD34208NICHD NIH HHS HD36801NICHD NIH HHS HD40485NICHD NIH HHS HD40500NICHD NIH HHS HD40512NICHD NIH HHS HD40544NICHD NIH HHS HD40545NICHD NIH HHS HD40560NICHD NIH HHS HD53097NICHD NIH HHS HD53118NICHD NIH HHS R24 HD050924NICHD NIH HHS U01 HD036801NICHD NIH HHS U10 HD021410NICHD NIH HHS U10 HD027869NICHD NIH HHS U10 HD027915NICHD NIH HHS U10 HD027917NICHD NIH HHS U10 HD034116NICHD NIH HHS U10 HD034208NICHD NIH HHS U10 HD036801NICHD NIH HHS U10 HD040485NICHD NIH HHS U10 HD040500NICHD NIH HHS U10 HD040512NICHD NIH HHS U10 HD040544NICHD NIH HHS U10 HD040545NICHD NIH HHS U10 HD040560NICHD NIH HHS U10 HD053097NICHD NIH HHS U10 HD053118NICHD NIH HHS U24 HD036801NICHD NIH HHS UG1 HD027869NICHD NIH HHS UG1 HD027915NICHD NIH HHS UG1 HD034116NICHD NIH HHS UG1 HD034208NICHD NIH HHS UG1 HD040485NICHD NIH HHS UG1 HD040500NICHD NIH HHS UG1 HD040512NICHD NIH HHS UG1 HD040544NICHD NIH HHS UG1 HD040545NICHD NIH HHS UG1 HD040560NICHD NIH HHS UG1 HD053097
6 · The paper itself

Abstract

objectiveTo estimate determinants of and outcomes associated with activity restriction among women with a short cervix.

methodsThis was a secondary analysis of a randomized trial of 17-α hydroxyprogesterone caproate for prevention of preterm birth among nulliparous women with singleton gestations and cervices less than 30 mm by midtrimester ultrasonography. Women were asked weekly whether they had been placed on pelvic, work, or nonwork rest. "Any activity restriction" was defined as being placed on any type of rest. Factors associated with any activity restriction were determined and the association between preterm birth and activity restriction was estimated with multivariable logistic regression.

resultsOf the 657 women in the trial, 646 (98%) responded to questions regarding activity restriction. Two hundred fifty-two (39.0%) were placed on any activity restriction at a median of 23.9 weeks (interquartile range 22.6-27.9 weeks). Women on activity restriction were older, more likely to have private insurance, less likely to be Hispanic, had a shorter cervical length, and were more likely to have funneling and intra-amniotic debris. Preterm birth at less than 37 weeks of gestation was more common among women placed on activity restriction (37% compared with 17%, P<.001). After controlling for potential confounding factors, preterm birth remained more common among those placed on activity restriction (adjusted odds ratio 2.37, 95% confidence interval 1.60-3.53). Results were similar for preterm birth at less than 34 weeks of gestation.

conclusionActivity restriction did not reduce the rate of preterm birth in asymptomatic nulliparous women with a short cervix.

Indexed as

ExerciseActivities of Daily LivingAdultFemaleHumansPregnancyPremature BirthRandomized Controlled Trials as TopicTreatment FailureUterine Cervical DiseasesYoung Adult

Identifiers

PMID23812450
PMCPMC4019312

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.