ArticleInternational journal of molecular sciences2013
Early phenylpropanoid biosynthetic steps in Cannabis sativa: link between genes and metabolites.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Chromatin accessibility directly governs flavonoid biosynthesis and indirectly orchestrates cannabinoid production inFrontiers in plant science · 2025Article
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- Transcriptomics and metabolomics reveal the primary and secondary metabolism changes inFrontiers in plant science · 2023Article
- Genome-wide identification of key enzyme-encoding genes and the catalytic roles of two 2-oxoglutarate-dependent dioxygenase involved in flavonoid biosynthesis in Cannabis sativa L.Microbial cell factories · 2022Article
- Towards a Cardoon (International journal of molecular sciences · 2021Article
- Flavonoids inACS omega · 2021Review
- In Silico Identification of MYB and bHLH Families Reveals Candidate Transcription Factors for Secondary Metabolic Pathways inPlants (Basel, Switzerland) · 2020Article
- Cell Suspensions ofMolecules (Basel, Switzerland) · 2019Article
- Evaluation of reference genes for real-time quantitative PCR analysis in southern corn rootworm, Diabrotica undecimpunctata howardi (Barber).Scientific reports · 2019Article
- Down regulation of p-coumarate 3-hydroxylase in petunia uniquely alters the profile of emitted floral volatiles.Scientific reports · 2019Article
- Transcript profiling of jasmonate-elicited Taxus cells reveals a β-phenylalanine-CoA ligase.Plant biotechnology journal · 2016Article
- Metabolic and Molecular Changes of the Phenylpropanoid Pathway in Tomato (Frontiers in plant science · 2016Article
- Cannabis sativa: The Plant of the Thousand and One Molecules.Frontiers in plant science · 2016Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenylalanine ammonia-lyase (PAL), Cinnamic acid 4-hydroxylase (C4H) and 4-Coumarate: CoA ligase (4CL) catalyze the first three steps of the general phenylpropanoid pathway whereas chalcone synthase (CHS) catalyzes the first specific step towards flavonoids production. This class of specialized metabolites has a wide range of biological functions in plant development and defence and a broad spectrum of therapeutic activities for human health. In this study, we report the isolation of hemp PAL and 4CL cDNA and genomic clones. Through in silico analysis of their deduced amino acid sequences, more than an 80% identity with homologues genes of other plants was shown and phylogenetic relationships were highlighted. Quantitative expression analysis of the four above mentioned genes, PAL and 4CL enzymatic activities, lignin content and NMR metabolite fingerprinting in different Cannabis sativa tissues were evaluated. Furthermore, the use of different substrates to assay PAL and 4CL enzymatic activities indicated that different isoforms were active in different tissues. The diversity in secondary metabolites content observed in leaves (mainly flavonoids) and roots (mainly lignin) was discussed in relation to gene expression and enzymatic activities data.
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