ArticleAJNR. American journal of neuroradiology2013
Sex differences in resting-state functional connectivity in multiple sclerosis.
Article in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Gender disparities in cognitive impairment across neurological autoimmune disorders: a systematic review.Frontiers in neurology · 2025Pooled it
- Imaging phenotypic differences in multiple sclerosis: at the crossroads of aging, sex, race, and ethnicity.Frontiers in global women's health · 2024Review
- Regional white matter and gray matter damage and cognitive performances in multiple sclerosis according to sex.Molecular psychiatry · 2023Article
- Differences in resting state functional connectivity relative to multiple sclerosis and impaired information processing speed.Frontiers in neurology · 2023Article
- Microstates in multiple sclerosis: an electrophysiological signature of altered large-scale networks functioning?Brain communications · 2023Article
- Potential biological contributers to the sex difference in multiple sclerosis progression.Frontiers in immunology · 2023Article
- A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?Molecular neurobiology · 2018Review
- Resting-state functional connectivity predicts neuroticism and extraversion in novel individuals.Social cognitive and affective neuroscience · 2018Article
- Functional Connectivity in Multiple Sclerosis: Recent Findings and Future Directions.Frontiers in neurology · 2018Review
- Male-to-female gender dysphoria: Gender-specific differences in resting-state networks.Brain and behavior · 2017Article
- Brain networks disconnection in early multiple sclerosis cognitive deficits: an anatomofunctional study.Human brain mapping · 2014Article
- Fornix as an imaging marker for episodic memory deficits in healthy aging and in various neurological disorders.Frontiers in aging neuroscience · 2014Review
- Alterations in knee sensorimotor brain functional connectivity contributes to ACL injury in male high-school football players: a prospective neuroimaging analysis.Brazilian journal of physical therapyArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeMultiple studies have demonstrated evidence of sex differences in patients with MS, including differences in disease progression, cognitive decline, and biologic markers. This study used functional connectivity MRI to investigate sex differences in the strength of functional connectivity of the default mode network in patients with MS and healthy control subjects. MATERIALS AND
methodsA total of 16 men and 16 women with MS and 32 age- and sex-matched healthy control subjects underwent a whole-brain resting-state functional connectivity MRI scan. A group-based seed in the posterior cingulate was used to create whole-brain correlation maps. A 2 × 2 ANOVA was used to assess whether disease status and sex affected the strength of connectivity to the posterior cingulate.
resultsPatients with MS showed significantly stronger connectivity from the posterior cingulate to the bilateral medial frontal gyri, the left ventral anterior cingulate, the right putamen, and the left middle temporal gyrus (P < .0005). In the left dorsal lateral prefrontal cortex, female patients showed significantly stronger connectivity to the posterior cingulate cortex compared with female control subjects (P = 3 × 10(4)), and male control subjects showed stronger posterior cingulate cortex-left dorsal lateral prefrontal cortex connectivity in comparison to female control subjects (P = .002). Male patients showed significantly weaker connectivity to the caudate compared with female patients (P = .004).
conclusionsDisease status and sex interact to produce differences in the strength of functional connectivity from the posterior cingulate to the caudate and the left dorsal lateral prefrontal cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.