ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2013
Latency of intracranial germ cell tumors and diagnosis delay.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review.Frontiers in endocrinology · 2021Pooled it
- Cerebrospinal Fluid Genomic Profiling as an Adjunct in a Case of Intracranial Germinoma: Utility and Limitations.Diagnostics (Basel, Switzerland) · 2026Article
- Intracranial germ cell tumors: advancement in genomic diagnostics and the need for novel therapeutics.Frontiers in oncology · 2025Review
- Germinoma of basal ganglia.Radiology case reports · 2024Article
- Absence of anti-rabphilin-3A antibodies in children and young adults with idiopathic central diabetes insipidus: a potential clue to elucidating a tumor etiology.Hormones (Athens, Greece) · 2023Review
- Occult neurohypophyseal germinoma discovered during the course of long-term diabetes insipidus: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Article
- Mediastinal metastases from a primary immature teratoma of the CNS.Radiology case reports · 2022Article
- Radiological Latency in Pineal Germinoma: A Case Report and Literature Review.Neuro-ophthalmology (Aeolus Press) · 2022Article
- Ectopic Germinoma: A Delayed Diagnosis With Serial Magnetic Resonance Imaging Features.Cureus · 2021Article
- Evaluation of RAPNO criteria in medulloblastoma and other leptomeningeal seeding tumors using MRI and clinical data.Neuro-oncology · 2020Article
- Secreting Germ Cell Tumors of the Central Nervous System: A Long-Term Follow-up Experience.Cancers · 2020Article
- Time to diagnosis and clinical characteristics in pediatric brain tumor patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Early diagnosis in a case of atypically located germinoma:Oxford medical case reports · 2019Article
- Symptoms in primary care with time to diagnosis of brain tumours.Family practice · 2018Article
- Intracranial Germ Cell Tumor in the Molecular Era.Journal of Korean Neurosurgical Society · 2018Review
- Primary Central Nervous System Germ Cell Tumors: A Review and Update.Medical research archives · 2018Article
- Presentation and symptom interval in children with central nervous system tumors. A single-center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Observational
- An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors.European journal of medical research · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracranial germ cell tumors (GCTs) frequently take an insidious clinical course before diagnosis. To date, clinical latency has been discussed in the context of germinoma in the suprasellar area and basal ganglia.
objectiveIn this study, we classified the clinical latency of intracranial GCTs into three categories and described their characteristics in order to understand the full spectrum of the phenomenon.
methodsIn a cohort of 181 patients with intracranial GCTs, 17 patients had a delayed diagnosis of more than 3 months (90 days) from the initial brain magnetic resonance imaging to the definitive GCT diagnosis. Clinical records and radiological data of the patients were reviewed.
resultsThe patients with a delayed diagnosis were categorized into three groups according to their tumor location: suprasellar (nine patients), basal ganglia (six patients), and pineal (two patients). Initial symptomatology corresponded with the tumor location: central diabetes insipidus for the suprasellar group, hemiparesis for the basal ganglia group, and precocious puberty for the pineal group. The overall survival of patients with germinoma and delayed diagnosis was significantly shorter than that of patients who were diagnosed within 3 months (P = 0.002).
conclusionsClinical latency and delayed diagnosis are not restricted to germinomas in the suprasellar area and basal ganglia; they are canonical features of intracranial GCTs including pineal non-germinomatous GCTs. Early detection and proactive diagnosis of these tumors are required because diagnosis delay may negatively influence patient survival.
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