ArticleThe Pediatric infectious disease journal2013
Invasive pneumococcal disease among children with and without sickle cell disease in the United States, 1998 to 2009.
Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Clinical effectiveness and impact of 13-valent pneumococcal conjugate vaccines in preventing invasive pneumococcal disease among children with risk conditions: A systematic literature review.Human vaccines & immunotherapeutics · 2026Pooled it
- Half a century of pneumococcal vaccination in sickle cell disease: Are we winning the battle or losing immunity?Vaccine · 2026Review
- Clinical Features and Outcomes of Pneumococcal Bacteremia in Children With Sickle Cell Disease in the Pneumococcal Conjugate Vaccine Era.Pediatric blood & cancer · 2025Article
- Serotype specific pneumococcal vaccine effectiveness in children with sickle cell disease: A two-decade analysis.Vaccine · 2025Article
- Prevention of Invasive Pneumococcal Disease Among Black or African American Children With and Without Sickle Cell Disease in the United States After Introduction of 13-Valent Pneumococcal Conjugate Vaccine, 2005 Through 2019.Pediatric blood & cancer · 2025Article
- Article
- Disparities in invasive pneumococcal disease, pneumonia, and otitis media among US children by comorbidity profile and insurance status.Frontiers in public health · 2025Observational
- The impact of social vulnerability on primary vaccine coverage in children with sickle cell disease.Frontiers in public health · 2025Article
- Respiratory management of acute chest syndrome in children with sickle cell disease.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Pneumococcal infections in children with sickle cell disease before and after pneumococcal conjugate vaccines.Blood advances · 2023Article
- Review
- Penicillin Prophylaxis in Patients With Sickle Cell Disease Beyond Age 5 Years.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- The Impact of Standardized Infectious Diseases Consultation on Postsplenectomy Care and Outcomes.Open forum infectious diseases · 2022Article
- Considerations When Aggregating Data to Measure Performance Across Levels of the Health Care System.Academic pediatrics · 2022Article
- Influenza vaccination rates and hospitalizations among Medicaid enrollees with and without sickle cell disease, 2009-2015.Pediatric blood & cancer · 2021Article
- Early viral reactivation despite excellent immune reconstitution following haploidentical Bone marrow transplant with post-transplant cytoxan for sickle cell disease.Transplant infectious disease : an official journal of the Transplantation Society · 2020Article
- Evaluation of Outcomes and Quality of Care in Children with Sickle Cell Disease Diagnosed by Newborn Screening: A Real-World Nation-Wide Study in France.Journal of clinical medicine · 2019Article
- Incidence of invasive Haemophilus influenzae infections in children with sickle cell disease.Pediatric blood & cancer · 2019Article
- Evaluation of newborn sickle cell screening programme in England: 2010-2016.Archives of disease in childhood · 2018Article
- Alteration of lymphocyte phenotype and function in sickle cell anemia: Implications for vaccine responses.American journal of hematology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundChildren with sickle cell disease (SCD) are at increased risk of illness and death from invasive pneumococcal disease (IPD). The introduction in 2000 of the 7-valent pneumococcal conjugate vaccine and penicillin prophylaxis for children with SCD has greatly reduced the incidence of IPD in this population. However, a recent report suggested an increase in cases of IPD in children with SCD.
methodsUsing data from Active Bacterial Core surveillance, we analyzed trends in hospitalizations, mortality and serotype among children with SCD compared with other children. We used neonatal screening data to estimate SCD population denominators for each Active Bacterial Core surveillance site.
resultsFrom 1998 to 2009, 3069 cases of IPD occurred among African-American children less than 18 years of age in the Active Bacterial Core surveillance catchment area. Of these, 127 (4.1%) had SCD identified by medical chart review and 185 (6.0%) had 1 or more IPD risk factors, excluding SCD. Rates of IPD among children with SCD declined by 53% (1118 vs. 530 per 100,000) whereas the overall rates among African-American children declined by 74% (54 to 14 per 100,000). For all time periods, children with SCD and IPD were more likely to be hospitalized (84%-92% vs. 31%-56%) and more likely to die (6%-17% vs. 1%-2%) than children with no risk factors.
conclusionsAlthough the rate of IPD in children with SCD has dropped dramatically since 7-valent pneumococcal conjugate vaccine introduction, the rate of IPD in children with SCD remains higher than that of the general population of African-American children, pointing to the need for more effective prevention efforts to prevent IPD in children with SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.