ArticleJournal of experimental botany2013
Functions of the lethal leaf-spot 1 gene in wheat cell death and disease tolerance to Puccinia striiformis.
Article in Journal of experimental botany, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 31 citations in OpenAlex.
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- A fungal pathogen suppresses host leaf senescence to increase infection.Nature communications · 2025Article
- A necessary considering factor for breeding: growth-defense tradeoff in plants.Stress biology · 2023Review
- QTL mapping: insights into genomic regions governing component traits of yield under combined heat and drought stress in wheat.Frontiers in genetics · 2023Article
- A comprehensive dynamic immune acetylproteomics profiling induced by Puccinia polysora in maize.BMC plant biology · 2022Article
- Maize metabolome and proteome responses to controlled cold stress partly mimic early-sowing effects in the field and differ from those of Arabidopsis.Plant, cell & environment · 2021Article
- Characterization of a novel allele encoding pheophorbide a oxygenase in rice.Plant signaling & behavior · 2021Article
- Commonly and Specifically Activated Defense Responses in Maize Disease Lesion Mimic Mutants Revealed by Integrated Transcriptomics and Metabolomics Analysis.Frontiers in plant science · 2021Article
- Chloroplasts and Plant Immunity: Where Are the Fungal Effectors?Pathogens (Basel, Switzerland) · 2019Review
- Identification and characterization of a spotted-leaf mutant spl40 with enhanced bacterial blight resistance in rice.Rice (New York, N.Y.) · 2019Article
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- Cloning and characterization of the pepper CaPAO gene for defense responses to salt-induced leaf senescence.BMC biotechnology · 2015Article
- Effect of Low Temperature and Wheat Winter-Hardiness on Survival of Puccinia striiformis f. sp. tritici under Controlled Conditions.PloS one · 2015Article
- Wheat TaNPSN SNARE homologues are involved in vesicle-mediated resistance to stripe rust (Puccinia striiformis f. sp. tritici).Journal of experimental botany · 2014Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Pheophorbide a oxygenase (PaO) is a key enzyme in chlorophyll catabolism that is known to suppress cell death in maize and Arabidopsis. The catalytic activity of PaO in chlorophyll degradation has been clearly demonstrated, but the function of PaO in the regulation of cell death and plant-microbe interactions is largely unknown. In this study, we characterized a PaO homologue in wheat of the lethal leaf-spot 1 gene, TaLls1, that was induced in leaves infected by Puccinia striiformis f.sp. tritici (Pst) and wounding treatment. The TaLls1 protein contains a conserved Rieske [2Fe-2S] motif and a mononuclear iron-binding site typical of PaOs. Silencing of TaLls1 by virus-induced gene silencing in wheat led to leaf cell death without pathogen attacks, possibly due to the accumulation of pheophorbide a (upstream substrate of PaO), indicating a suppressor role of TaLls1, while overexpression of TaLls1 also triggered cell death in both tobacco and wheat leaves, probably owing to the accumulation of the red chlorophyll catabolite (downstream product of PaO). Further deletion mutant analysis showed that the conserved Rieske domain, but not the iron-binding site, was essential for cell death induction. These results thus suggest a threshold for TaLls1 in maintaining cell homeostasis to adapt in various stresses, and shed new light on the role of TaLls1 in cell death regulation. Furthermore, silencing of TaLls1 in wheat did not change the disease symptoms but enhanced tolerance to Pst via an significant increase in H2O2 generation, elevated cell death occurrence, and upregulation of pathogenesis-related genes.
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