ArticleScience (New York, N.Y.)2013
Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans.
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The nonsense-mediated decay RNA-surveillance pathway facilitates the hypoxia response bybioRxiv : the preprint server for biology · 2026Article
- Molecular mechanisms of CYP-13 function in C. elegans: insights into conserved P450 pathways.Archives of toxicology · 2026Review
- Induction and regulation of reversible suspended animation in C. elegans.Nature communications · 2026Article
- Article
- Induction and regulation of a reversible form of suspended animation inbioRxiv : the preprint server for biology · 2026Article
- Article
- Sex Alters Hypoxic Responses inmicroPublication biology · 2026Article
- Non-visual light modulates behavioral memory and gene expression inbioRxiv : the preprint server for biology · 2025Article
- Conserved lipid metabolic reprogramming confers hypoxic and aging resilience.bioRxiv : the preprint server for biology · 2025Article
- Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Role ofInsects · 2024Article
- Suppressing APOE4-induced mortality and cellular damage by targeting VHL.bioRxiv : the preprint server for biology · 2024Article
- Article
- ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans.PLoS biology · 2022Article
- A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans.Nature communications · 2022Article
- Turning the Oxygen Dial: Balancing the Highs and Lows.Trends in cell biology · 2020Review
- N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance.Science advances · 2020Article
- The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1α in cerebral ischemia-reperfusion injury.Drug design, development and therapy · 2019Article
- Article
- Lipid and Carbohydrate Metabolism inGenetics · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Oxygen deprivation followed by reoxygenation causes pathological responses in many disorders, including ischemic stroke, heart attacks, and reperfusion injury. Key aspects of ischemia-reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2-ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2-sensing HIF (hypoxia-inducible factor) hydroxylase EGL-9. From a genetic screen, we found that the cytochrome P450 oxygenase CYP-13A12 acts in response to the EGL-9-HIF-1 pathway to facilitate the O2-ON response. CYP-13A12 promotes oxidation of polyunsaturated fatty acids into eicosanoids, signaling molecules that can strongly affect inflammatory pain and ischemia-reperfusion injury responses in mammals. We propose that roles of the EGL-9-HIF-1 pathway and cytochrome P450 in controlling responses to reoxygenation after anoxia are evolutionarily conserved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.