ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Do changes in circulating biomarkers track with each other and with functional changes in older adults?
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
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- ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design.Journal of the American Geriatrics Society · 2017Trial
- Effect of Intensive Blood Pressure Control on Gait Speed and Mobility Limitation in Adults 75 Years or Older: A Randomized Clinical Trial.JAMA internal medicine · 2017Trial
- Inflammatory Biomarkers and Cognitive Decline: The Ginkgo Evaluation of Memory Study.Journal of the American Geriatrics Society · 2016Trial
- Pace of Aging analysis of healthspan and lifespan in older adults in the US and UK.Nature aging · 2025Article
- Pace of Aging in older adults matters for healthspan and lifespan.medRxiv : the preprint server for health sciences · 2024Article
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
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- Integrating DNA Methylation Measures of Biological Aging into Social Determinants of Health Research.Current environmental health reports · 2022Review
- Associations of Circulating Insulin-Growth Factor-1 With Cognitive Functions and Quality of Life Domains in Ambulatory Young Adults With Cerebral Palsy: A Pilot Study.Frontiers in neurology · 2022Article
- Derivation of a measure of physiological multisystem dysregulation: Results from WHAS and health ABC.Mechanisms of ageing and development · 2020Article
- Sex-specific muscle and metabolic biomarkers associated with gait speed and cognitive transitions in older adults: a 9-year follow-up.GeroScience · 2020Article
- Multisystem Trajectories Over the Adult Life Course and Relations to Cardiovascular Disease and Death.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- A novel biomarker of cardiometabolic pathology in schizophrenia?Journal of psychiatric research · 2019Article
- The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations.Experimental gerontology · 2018Review
- Trajectories of IGF-I Predict Mortality in Older Adults: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Observational
- Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?American journal of epidemiology · 2018Article
- The Association Between Lipoproteins, Disability, and Physical Function Among Older Costa Rican Adults.Journal of aging and health · 2018Article
- The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging.Neurobiology of aging · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIt is unclear if changes in proposed circulating biomarkers of aging are strongly correlated to each other or functional change. We tested if biomarker changes track with each other and with functional measures over 9 years in older adults.
methodsDehydroepiandrosterone sulfate (DHEAS), adiponectin, insulin-like growth factor 1 (IGF-1), IGF binding proteins 1 (IGFBP-1) and 3 (IGFBP-3), interleukin-6 (IL-6), cholesterol, and function (gait speed, grip strength, Modified Mini Mental Status Exam [3MSE] and Digit Symbol Substitution Test [DSST] scores) were measured in 1996-1997 and 2005-2006 in the Cardiovascular Health Study All Stars study (N = 901, mean [standard deviation, SD] age 85.3 [3.6] years in 2005-2006). Adjusted Pearson correlations illustrated if biomarkers tracked together. Multivariable linear regression demonstrated if biomarker changes tracked with functional changes.
resultsCorrelations among biomarker changes were mostly <0.2. In models with each biomarker entered separately, a 1-SD increase biomarker change was associated with change in function as follows: grip strength (DHEAS β = 0.61kg, p = .001; IL-6 β = -0.46kg, p = .012; cholesterol men β = 0.79kg, p = .016); gait speed (DHEAS β = 0.02 meters per second, p = .039; IL-6 β = -0.018 meters per second, p = .049); and DSST score (DHEAS women β = 1.46, p = .004; IL-6 β = -0.83, p = .027). When biomarkers were entered in the same model, significant associations remaining were as follows: grip strength (DHEAS β = 0.54kg, p = .005; IL-6 β = -0.43kg, p = .022); 3MSE score (IGF-1 β = 0.96, p = .04; IGFBP-3 β = -1.07, p = .024); and DSST score (DHEAS women β = 1.27, p = .012; IL-6 β = -0.80, p = .04).
conclusionChanges in biomarkers were poorly correlated, supporting a model of stochastic, independent change across systems. DHEAS and IL-6 tracked most closely with function, illustrating that changes in inflammation and sex steroids may play dominant roles in changes of these functional outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.