ReviewMicrobes and infection
NLRP6 in infection and inflammation.
Review in Microbes and infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.Nature communications · 2026Article
- Loss of NLRP6 expression increases the severity of intestinal injury after syngeneic hematopoietic stem cell transplantation.Annals of hematology · 2024Article
- Nod-like receptors in inflammatory arthritis.Biomedical journal · 2024Review
- Role of the inflammasome in insulin resistance and type 2 diabetes mellitus.Frontiers in immunology · 2023Review
- Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation.Immunologic research · 2022Review
- NLRP7: From inflammasome regulation to human disease.Immunology · 2021Review
- ATP-Binding and Hydrolysis in Inflammasome Activation.Molecules (Basel, Switzerland) · 2020Review
- Transcriptome Based Profiling of the Immune Cell Gene Signature in Rat Experimental Colitis and Human IBD Tissue Samples.Biomolecules · 2020Article
- Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in Rats.Journal of molecular neuroscience : MN · 2019Article
- The protective roles of NLRP6 in intestinal epithelial cells.Cell proliferation · 2019Review
- LRP6 targeting suppresses gastric tumorigenesis via P14Oncotarget · 2017Article
- The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.Immunology · 2017Article
- Article
- Inflammasomes in Myeloid Cells: Warriors Within.Microbiology spectrum · 2017Review
- Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects.Molecular medicine reports · 2016Article
- Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes.Journal of neuroinflammation · 2015Article
- Inflammasomes.Cold Spring Harbor perspectives in biology · 2014Review
- Collaborative action of Toll-like and NOD-like receptors as modulators of the inflammatory response to pathogenic bacteria.Mediators of inflammation · 2014Review
- Debug Your Bugs - How NLRs Shape Intestinal Host-Microbe Interactions.Frontiers in immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
NLRs play fundamental roles in host-defense and inflammatory disorders. NLRP6 is a newly characterized member of this family that inhibits NF-κB and MAP-kinase dependent immune signaling to hamper anti-microbial defense. Further, NLRP6 regulates intestinal inflammation by maintaining gut microbiota composition. In this review, we examine the recent studies and emphasize the key functions regulated by NLRP6.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.