Evidence map›Paper›PMID 23810996›Full record

ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2013

The catechol-o-methyltransferase Val158 Met polymorphism modulates organization of regional cerebral blood flow response to working memory in adults.

Alicia F Heim, Melissa J Coyne, M Ilyas Kamboh, Christopher Ryan, J Richard Jennings

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alicia F HeimTDH E-1329 Psychophysiology Lab, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: heimaf@upmc.edu.
Melissa J Coyne
M Ilyas Kamboh
Christopher Ryan
J Richard Jennings
University of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
COGNITIVE AND CEREBROVASCULAR SEQUELAE OF HYPERTENSIONR01HL057529 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNINGS, JOHN RICHARD · 1997 to 2004
$2.7M
The Brain as a Target for Pre and Essential HypertensionR01HL101959 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNINGS, JOHN RICHARD · 2010 to 2014
$2.1M
NCATS NIH HHS UL1 TR000005NHLBI NIH HHS HL101959NHLBI NIH HHS HL57529NHLBI NIH HHS P01 HL040962NHLBI NIH HHS R01 HL057529NHLBI NIH HHS R01 HL101959NIA NIH HHS AG03653
6 · The paper itself

Abstract

This study examined the effect of catechol-o-methyltransferase (COMT) Val(158)Met genotypes on the co-activation of brain areas involved in cognition during a working memory (WM) task. The pattern of concomitant region of interest (ROI) activation during WM performance varied by genotype: Val/Val showing the least and Met/Met the most covariance. There were no differences of performance on the WM task between the COMT genotypes. However, relatively better performance was associated with less concomitance of dorsolateral prefrontal cortex (DLPFC) and cingulate cortex for Val/Val, but more concomitance of DLPFC with AH for Met/Met. Within genotypes WM performance was significantly correlated with rCBF to the amygdala/hippocampus (AH) for Val/Val (r = 0.44, p = 0.009), to the parietal lobe for Val/Met (r = 0.29, p = 0.03), and to the thalamus for Met/Met (r = 0.32, p = 0.04). Different genotypes showed different regional specificity and concomitant activation patterns suggesting that varying dopamine availability induces different brain processing pathways to achieve similar WM performance.

Indexed as

Polymorphism, GeneticAdultAgedAge FactorsBlood PressureCatechol O-MethyltransferaseCerebral CortexCerebrovascular CirculationFemaleHumansMaleMemory, Short-TermMethionineMiddle AgedPhotic StimulationPositron-Emission TomographyCatechol O-MethyltransferaseMethionineValineAHamygdala/hippocampuscatechol-o-methyltransferaseCatechol-o-methyltransferase (COMT)COMTDADLPFCdopamineDopaminedorsolateral prefrontal cortexPETregion of interestROIWMworking memoryWorking memory

Identifiers

PMID23810996
PMCPMC3818354
OpenAlexW2088175856

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.