ArticleBiological psychiatry2013
Indiscriminate amygdala response to mothers and strangers after early maternal deprivation.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Early Parenting Intervention Effects on Brain Responses to Maternal Cues Among High-Risk Children.The American journal of psychiatry · 2020Trial
- Signs of reactive attachment disorder and disinhibited social engagement disorder at age 12 years: Effects of institutional care history and high-quality foster care.Development and psychopathology · 2017Trial
- Effect of early institutionalization and foster care on long-term white matter development: a randomized clinical trial.JAMA pediatrics · 2015Trial
- Disrupted maternal care alters neural-microglia interactions in the primate paralaminar (PL) nucleus of the amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Impacts of early deprivation on behavioral and neural measures of executive function in early adolescence.Brain and cognition · 2024Article
- The impact of out-of-home care on brain development: a brief review of the neuroscientific evidence informing our understanding of children's attachment outcomes.Frontiers in behavioral neuroscience · 2024Review
- The Added Value of Crosstalk Between Developmental Circuit Neuroscience and Clinical Practice to Inform the Treatment of Adolescent Anxiety.Biological psychiatry global open science · 2023Review
- Lasting impact of postnatal maternal separation on the developing BNST: Lifelong socioemotional consequences.Neuropharmacology · 2023Review
- Early life adversity shapes neural circuit function during sensitive postnatal developmental periods.Translational psychiatry · 2022Review
- Timing of adoption is associated with electrophysiological brain activity and externalizing problems among children adopted internationally.Developmental psychobiology · 2022Article
- The Pubertal Stress Recalibration Hypothesis: Potential Neural and Behavioral Consequences.Child development perspectives · 2021Article
- Parental emotional support and social buffering in previously institutionalized and typically developing children and adolescents.Developmental psychobiology · 2021Article
- A Social Affective Neuroscience Model of Risk and Resilience in Adolescent Depression: Preliminary Evidence and Application to Sexual and Gender Minority Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Neural meaning making, prediction, and prefrontal-subcortical development following early adverse caregiving.Development and psychopathology · 2020Review
- Article
- Amygdala growth from youth to adulthood in the macaque monkey.The Journal of comparative neurology · 2019Article
- Childhood Adversity and Neural Development: A Systematic Review.Annual review of developmental psychology · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn altricial species, maternal stimuli have powerful effects on amygdala development and attachment-related behaviors. In humans, maternal deprivation has been associated with both "indiscriminate friendliness" toward non-caregiving adults and altered amygdala development. We hypothesized that maternal deprivation would be associated with reduced amygdala discrimination between mothers and strangers and increased parent report of indiscriminate friendliness behaviors.
methodsSixty-seven youths (33 previously institutionalized; 34 comparison; age-at-scan 4-17 years) participated in a functional magnetic resonance imaging experiment designed to examine amygdala response to mother versus stranger faces. In-scanner behavior was measured. Indiscriminate friendliness was assessed with parental report.
resultsComparison youth showed an amygdala response that clearly discriminated mother versus stranger stimuli. Previously institutionalized youths, by contrast, exhibited reduced amygdala discrimination between mothers and strangers. Reduced amygdala differentiation correlated with greater reports of indiscriminate friendliness. These effects correlated with age-at-adoption, with later adoptions being associated with reduced amygdala discrimination and more indiscriminate friendliness.
conclusionsOur results suggest that early maternal deprivation is associated with reduced amygdala discrimination between mothers and strangers, and reduced amygdala discrimination was associated with greater reports of indiscriminate friendliness. Moreover, these effects increased with age-at-adoption. These data suggest that the amygdala, in part, is associated with indiscriminate friendliness and that there might be a dose-response relationship between institutional rearing and indiscriminate friendliness.
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