ArticleCurrent biology : CB2013
Changes in cell morphology are coordinated with cell growth through the TORC1 pathway.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Alterations of actin in aging.Journal of cell science · 2026Review
- Kinase signaling cascades: an updated mechanistic landscape.Chemical science · 2025Review
- Potential Strategies Applied byPathogens (Basel, Switzerland) · 2025Article
- Regulatory dynamics of Sch9 in response to cytosolic acidification: From spatial reconfiguration to cellular adaptation to stresses.iScience · 2025Article
- The environmental stress response regulates ribosome content in cell cycle-arrestedFrontiers in cell and developmental biology · 2023Article
- TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle.Journal of cell science · 2022Article
- What programs the size of animal cells?Frontiers in cell and developmental biology · 2022Review
- The NPR/Hal family of protein kinases in yeasts: biological role, phylogeny and regulation under environmental challenges.Computational and structural biotechnology journal · 2022Review
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- Excised linear introns regulate growth in yeast.Nature · 2019Article
- A minimal "push-pull" bistability model explains oscillations between quiescent and proliferative cell states.Molecular biology of the cell · 2018Article
- Scaling up genetic circuit design for cellular computing: advances and prospects.Natural computing · 2018Article
- Testing the neutral hypothesis of phenotypic evolution.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2.The Journal of cell biology · 2017Article
- Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.European journal of medicinal chemistry · 2017Article
- The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth.Frontiers in cell and developmental biology · 2017Review
- Multiparameter mechanical and morphometric screening of cells.Scientific reports · 2016Article
- Experimental Evolution Reveals Interplay between Sch9 and Polyploid Stability in Yeast.PLoS genetics · 2016Article
- Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis: A NOVEL THERAPEUTIC POTENTIAL FOR ISCHEMIA.The Journal of biological chemistry · 2015Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundGrowth rate is determined not only by extracellular cues such as nutrient availability but also by intracellular processes. Changes in cell morphology in budding yeast, mediated by polarization of the actin cytoskeleton, have been shown to reduce cell growth.
resultsHere we demonstrate that polarization of the actin cytoskeleton inhibits the highly conserved Target of Rapamycin Complex 1 (TORC1) pathway. This downregulation is suppressed by inactivation of the TORC1 pathway regulatory Iml1 complex, which also regulates TORC1 during nitrogen starvation. We further demonstrate that attenuation of growth is important for cell recovery after conditions of prolonged polarized growth.
conclusionsOur results indicate that extended periods of polarized growth inhibit protein synthesis, mass accumulation, and the increase in cell size at least in part through inhibiting the TORC1 pathway. We speculate that this mechanism serves to coordinate the ability of cells to increase in size with their biosynthetic capacity.
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