ArticleBioorganic & medicinal chemistry2013
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Article in Bioorganic & medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Kinetic and Structural Characterization ofBiochemistry · 2023Article
- Approaches to the synthesis of heterocyclicRussian chemical bulletin = Izvestiia Akademii nauk. Seriia khimicheskaia · 2023Review
- Inhibition and Mechanism ofACS chemical biology · 2022Article
- The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues.Bioorganic & medicinal chemistry · 2022Article
- Kinetic Characterization and Inhibition ofBiochemistry · 2022Article
- Overview of Biologically Active Nucleoside Phosphonates.Frontiers in chemistry · 2020Review
- Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate asBiomolecules · 2019Article
- Enzymatic Transition States and Drug Design.Chemical reviews · 2018Review
- New Antibiotic Candidates against Helicobacter pylori.Journal of the American Chemical Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The pathogenic protozoa responsible for malaria lack enzymes for the de novo synthesis of purines and rely on purine salvage from the host. In Plasmodium falciparum (Pf), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) converts hypoxanthine to inosine monophosphate and is essential for purine salvage making the enzyme an anti-malarial drug target. We have synthesized a number of simple acyclic aza-C-nucleosides and shown that some are potent inhibitors of Pf HGXPRT while showing excellent selectivity for the Pf versus the human enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.