ArticleThe Journal of allergy and clinical immunology2013
Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 95 citations in OpenAlex.
- Exploring novel systemic biomarker approaches in grass-pollen sublingual immunotherapy using omics.Allergy · 2021Trial
- Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies.European journal of immunology · 2025Review
- Emerging diagnostic and therapeutic opportunities in food allergy.Frontiers in immunology · 2025Review
- Shrimp allergen extract immunotherapy induces prolonged immune tolerance in a gastro-food allergy mouse model.PloS one · 2024Article
- Single center experience with more than 600 drug desensitization in Colombia.Frontiers in allergy · 2024Article
- Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines.ACS nano · 2023Article
- Multistep IgE Mast Cell Desensitization Is a Dose- and Time-Dependent Process Partially Regulated by SHIP-1.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Review
- Temporal Modulation of Drug Desensitization Procedures.Current issues in molecular biology · 2022Review
- Desensitization for the prevention of drug hypersensitivity reactions.The Korean journal of internal medicine · 2022Review
- Review
- Findings ofFrontiers in allergy · 2022Article
- Mast Cell Desensitization in Allergen Immunotherapy.Frontiers in allergy · 2022Review
- Oral Immunotherapy for Children with Cow's Milk Allergy.Pathogens (Basel, Switzerland) · 2021Review
- Nanoparticles Displaying Allergen and Siglec-8 Ligands Suppress IgE-FcεRI-Mediated Anaphylaxis and Desensitize Mast Cells to Subsequent Antigen Challenge.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.Mucosal immunology · 2021Article
- Mechanisms of oral immunotherapy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Review
- Article
- Ephedra Herb, Mao, Inhibits Antigen-Induced Mast Cell Degranulation by Induction of the Affinity Receptor for IgE Internalization.Pharmaceutical research · 2021Article
- Converter Phenotype: A New Profile That Is Not Exclusive to Taxanes.Frontiers in allergy · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRapid desensitization transiently prevents severe allergic reactions, allowing administration of life-saving therapies in previously sensitized patients. However, the mechanisms underlying successful rapid desensitization are not fully understood.
objectivesWe sought to investigate whether the mast cell (MC) is an important target of rapid desensitization in mice sensitized to exhibit IgE-dependent passive systemic anaphylaxis in vivo and to investigate the antigen specificity and underlying mechanisms of rapid desensitization in our mouse model.
methodsC57BL/6 mice (in vivo) or primary isolated C57BL/6 mouse peritoneal mast cells (PMCs; in vitro) were passively sensitized with antigen-specific anti-2,4-dinitrophenyl IgE, anti-ovalbumin IgE, or both. MCs were exposed over a short period of time to increasing amounts of antigen (2,4-dinitrophenyl-human serum albumin or ovalbumin) in the presence of extracellular calcium in vitro or by means of intravenous administration to sensitized mice in vivo before challenging the mice with or exposing the PMCs to optimal amounts of specific or irrelevant antigen.
resultsRapidly exposing mice or PMCs to progressively increasing amounts of specific antigen inhibited the development of antigen-induced hypothermia in sensitized mice in vivo and inhibited antigen-induced PMC degranulation and prostaglandin D2 synthesis in vitro. Such MC hyporesponsiveness was induced antigen-specifically and was associated with a significant reduction in antigen-specific IgE levels on MC surfaces.
conclusionsRapidly exposing MCs to progressively increasing amounts of antigen can both enhance the internalization of antigen-specific IgE on the MC surface and also desensitize these cells in an antigen-specific manner in vivo and in vitro.
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Registered trials
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