ArticleBehavioural brain research2013
Cholinergic receptor activation supports persistent firing in layer III neurons in the medial entorhinal cortex.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- GATE: Adaptive learning with working memory by information gating in multi-lamellar hippocampal formation.PLoS computational biology · 2026Article
- Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.Progress in neurobiology · 2025Article
- A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation.Nature communications · 2024Article
- Spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity.Nature communications · 2024Article
- Cholinergic modulation of persistent inward currents is mediated by activating muscarinic receptors of serotonergic neurons in the brainstem of ePet-EYFP mice.Experimental brain research · 2022Article
- Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons.Frontiers in psychiatry · 2022Article
- Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices.Frontiers in systems neuroscience · 2020Review
- Differential responsivity of neurons in perirhinal cortex, lateral entorhinal cortex, and dentate gyrus during time-bridging learning.Hippocampus · 2019Article
- A neural microcircuit model for a scalable scale-invariant representation of time.Hippocampus · 2019Article
- Potential roles of cholinergic modulation in the neural coding of location and movement speed.Journal of physiology, Paris · 2016Review
- A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex.Journal of visualized experiments : JoVE · 2016Article
- A behavioral defect of temporal association memory in mice that partly lack dopamine reuptake transporter.Scientific reports · 2015Article
- Entorhinal-hippocampal neuronal circuits bridge temporally discontiguous events.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Current questions on space and time encoding.Hippocampus · 2015Review
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4 authors.
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Abstract
Medial temporal lobe (MTL) areas are crucial for memory tasks such as spatial working memory and temporal association memory, which require an active maintenance of memory for a short period of time (a few hundred milliseconds to tens of seconds). Recent work has shown that the projection from layer III neurons in the medial entorhinal cortex (MEC) to hippocampal region CA1, the temporoammonic (TA) pathway, might be specially important for these memory tasks. In addition, lesions to the entorhinal cortex disrupt persistent firing in CA1 which is believed to support active maintenance of memory. Injection of cholinergic antagonists and group I mGlu receptor antagonists to the MEC impairs spatial working memory and temporal association memory. Consistent with this, we have shown that group I mGlu receptor activation supports persistent firing in principal cells of the MEC layer III in vitro (Yoshida et al. [39]). However, it still remains unknown whether cholinergic receptor activation also supports persistent firing in MEC layer III neurons. In this paper, we tested this in MEC layer III cells using both ruptured and perforated whole-cell recordings in vitro. We report that the majority of cells we recorded from in MEC layer III show persistent firing during perfusion of the cholinergic agonist carbachol (2-10μM). In addition, repeated stimulation gradually suppressed persistent firing. We further discuss the possible role of persistent firing in memory function in general.
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