ArticleCell2013
Genetic and neural mechanisms that inhibit Drosophila from mating with other species.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 166 citations in OpenAlex.
- Cross-Species Social Experience Suppresses Aggression in Drosophila.Neuroscience bulletin · 2026Article
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- Sex-specific behavioral feedback modulates sensorimotor processing and drives flexible social behavior.Nature communications · 2026Article
- Evolutionary basis of male same-sex sexual behavior by multiple pheromone switches in Drosophila.Current biology : CB · 2026Article
- Strain variation identifies a neural substrate for behavioral evolution in Drosophila.Current biology : CB · 2026Article
- Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026Review
- High-throughput tracking of freely moving Drosophila reveals variations in aggression and courtship behaviors.Scientific reports · 2025Article
- From neurons to novelty: Circuit mechanisms shaping courtship evolution.Current opinion in neurobiology · 2025Review
- Evolutionary basis of intermale sexual behavior by multiple pheromone switches inbioRxiv : the preprint server for biology · 2025Article
- Strain variation identifies a neural substrate for behavioral evolution inbioRxiv : the preprint server for biology · 2025Article
- High-Throughput Tracking of Freely MovingbioRxiv : the preprint server for biology · 2025Article
- Sexually-dimorphic neurons in theResearch square · 2025Article
- Sexually-dimorphic neurons in thebioRxiv : the preprint server for biology · 2025Article
- Regulatory changes in the fatty acid elongase eloF underlie the evolution of sex-specific pheromone profiles in Drosophila prolongata.BMC biology · 2025Article
- Function and evolution of Ir52 receptors in mate detection in Drosophila.Current biology : CB · 2024Article
- Article
- Regulatory Changes in the Fatty Acid ElongasebioRxiv : the preprint server for biology · 2024Article
- Article
- Functional labeling of individualized postsynaptic neurons using optogenetics and trans-Tango in Drosophila (FLIPSOT).PLoS genetics · 2024Article
- Genetics and the Evolution of Prezygotic Isolation.Cold Spring Harbor perspectives in biology · 2024Review
43 more citing papers are in PubMed but not listed here.
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11 authors at 4 institutions in 2 countries.
Funding
Abstract
Genetically hard-wired neural mechanisms must enforce behavioral reproductive isolation because interspecies courtship is rare even in sexually naïve animals of most species. We find that the chemoreceptor Gr32a inhibits male D. melanogaster from courting diverse fruit fly species. Gr32a recognizes nonvolatile aversive cues present on these reproductively dead-end targets, and activity of Gr32a neurons is necessary and sufficient to inhibit interspecies courtship. Male-specific Fruitless (Fru(M)), a master regulator of courtship, also inhibits interspecies courtship. Gr32a and Fru(M) are not coexpressed, but Fru(M) neurons contact Gr32a neurons, suggesting that these genes influence a shared neural circuit that inhibits interspecies courtship. Gr32a and Fru(M) also suppress within-species intermale courtship, but we show that distinct mechanisms preclude sexual displays toward conspecific males and other species. Although this chemosensory pathway does not inhibit interspecies mating in D. melanogaster females, similar mechanisms appear to inhibit this behavior in many other male drosophilids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.