ReviewTrends in biotechnology2013
Inverting hydrolases and their use in enantioconvergent biotransformations.
Review in Trends in biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Hijacking Chemical Reactions of P450 Enzymes for Altered Chemical Reactions and Asymmetric Synthesis.International journal of molecular sciences · 2022Review
- The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions.Journal of the American Chemical Society · 2021Article
- Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation.Chembiochem : a European journal of chemical biology · 2021Article
- Mini Review: Advances in 2-Haloacid Dehalogenases.Frontiers in microbiology · 2021Review
- Synthesis of enantiomerically pure alcohols and aminesCatalysis science & technology · 2019Article
- Enzymatic synthesis of enantiopure alcohols: current state and perspectives.RSC advances · 2019Review
- Resolution of Atropisomeric Cyclic Catechol MonoetherACS omega · 2018Article
- Improved activity of lipase immobilized in microemulsion-based organogels for (Biotechnology reports (Amsterdam, Netherlands) · 2015Article
- A broadly applicable and practical oligomeric (salen) Co catalyst for enantioselective epoxide ring-opening reactions.Tetrahedron · 2014Article
- Stereochemistry and Mechanism of Enzymatic and Non-Enzymatic Hydrolysis of BenzylicEuropean journal of organic chemistry · 2014Article
- Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion.Angewandte Chemie (International ed. in English) · 2014Article
- Microbial alkyl- and aryl-sulfatases: mechanism, occurrence, screening and stereoselectivities.Applied microbiology and biotechnology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to the more abundant occurrence of racemic compounds compared to prochiral or meso forms, most enantiomerically pure products are obtained via racemate resolution. This review summarizes (chemo)enzymatic enantioconvergent processes based on the use of hydrolytic enzymes, which are able to invert a stereocenter during catalysis that can overcome the 50%-yield limitation of kinetic resolution. Recent developments are presented in the fields of inverting or retaining sulfatases, epoxide hydrolases and dehalogenases, which allow the production of secondary alcohols or vicinal diols at a 100% theoretical yield from a racemate via enantioconvergent processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.