ArticleThe journal of spinal cord medicine2013
Sperm chromatin condensation, DNA integrity, and apoptosis in men with spinal cord injury.
Article in The journal of spinal cord medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Provocative stimulation of the hypothalamic-pituitary-testicular axis in men with spinal cord injury.Spinal cord · 2016Trial
- Spinal Cord Injury-Related Male Infertility: Oxidative Stress, Inflammation, and Sperm DNA Damage.Journal of clinical medicine · 2026Review
- Article
- Quality of testicular spermatozoa improves with changes in composition of culture medium.Basic and clinical andrology · 2023Article
- Analysis of sperm chromatin packaging and reproductive biomarker to evaluate the consequence of advanced male age.Frontiers in endocrinology · 2023Article
- Prolonged semen incubation alters the biological characteristics of human spermatozoa.Clinical and experimental reproductive medicine · 2022Article
- The effects of morphine abuse on sperm parameters, chromatin integrity and apoptosis in men.JBRA assisted reproduction · 2022Article
- Article
- The effect of human sperm chromatin maturity on ICSI outcomes.Human cell · 2018Article
- Lipid Peroxidation and Its Role in the Expression of NLRP1a and NLRP3 Genes in Testicular Tissue of Male Rats: a Model of Spinal Cord InjuryIranian biomedical journal · 2018Article
- Sperm chromatin and DNA integrity, methyltransferase mRNA levels, and global DNA methylation in oligoasthenoteratozoospermia.Clinical and experimental reproductive medicine · 2018Article
- The etiologies of DNA abnormalities in male infertility: An assessment and review.International journal of reproductive biomedicine · 2017Review
- Evaluation of sperm protamine deficiency and apoptosis in infertile men with idiopathic teratozoospermia.Clinical and experimental reproductive medicine · 2017Article
- Evaluation of intracellular anion superoxide level, heat shock protein A2 and protamine positive spermatozoa percentages in teratoasthenozoospermia.International journal of reproductive biomedicine · 2017Article
- Relationship between sperm protamine deficiency and apoptosis in couples with unexplained repeated spontaneous abortions.International journal of reproductive biomedicine · 2016Article
- Sperm parameters, protamine deficiency, and apoptosis in total globozoospermia.Iranian journal of reproductive medicine · 2015Article
- Evaluation of Sperm Chromatin Integrity Using Aniline Blue and Toluidine Blue Staining in Infertile and Normozoospermic Men.Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the effect of cord injury on (1) sperm parameters and (2) DNA chromatin status.
designCase-control study.
settingData were collected from men referred to Research and Clinical Center for Infertility, Yazd, Iran.
participantsThirty infertile men with the presence of any level of spinal cord injury (SCI) were compared with 30 healthy donors with definite fertility and normal sperm parameters.
interventionsNot applicable. OUTCOME MEASURES: Sperm chromatin integrity was assessed using aniline blue (AB), chromomycin A3 (CMA3), toluidine blue (TB), and acridine orange (AO) assays. The rate of apoptotic spermatozoa was evaluated with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) staining.
resultsSperm concentration, motility, and morphology in men with SCI were significantly decreased compared with control group (P < 0.05). In addition, with regard to cytochemical staining and TUNEL test, the rate of reacted spermatozoa was increased significantly in SCI group when compared with the controls (P < 0.05). The majority of AB, TB, AO, and CMA3-reacted spermatozoa were higher than the "cut-off" value in men with SCI, as were the number of apoptotic spermatozoa stained with TUNEL.
conclusionResults showed that SCI disturbs sperm parameters, nuclear maturity, and DNA integrity of spermatozoa. Therefore, the production of spermatozoa with less condensed chromatin and more apoptotic rate increases after cord injury and this may be one possible cause of infertility following SCI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.