ArticleThe journal of spinal cord medicine2013
The association of opioid use with incident lower extremity fractures in spinal cord injury.
Article in The journal of spinal cord medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Prevalence and psychosocial interventions of mental disorders following traumatic spinal cord injury: a systematic review and meta-analysis based on knowledge graphs.BMC psychiatry · 2026Pooled it
- Prevalence of opioid use in adults with spinal cord injury: A systematic review and meta-analysis.The journal of spinal cord medicine · 2025Pooled it
- Pooled it
- Pooled it
- Management of Mental Health Disorders, Substance Use Disorders, and Suicide in Adults with Spinal Cord Injury: Clinical Practice Guideline for Healthcare Providers.Topics in spinal cord injury rehabilitationGuideline
- Community opioid dispensing prevalence and patterns in adults with spinal cord injury in Queensland: a retrospective data linkage study.Spinal cord · 2025Article
- Prescription opioid dispensing rates in the 12-months post-discharge after acute spinal cord injury: An observational study.The journal of spinal cord medicine · 2025Observational
- Post-operative opioid utilization after surgery for spinal trauma: a retrospective study at a level 1 trauma center.Journal of spine surgery (Hong Kong) · 2025Article
- Polypharmacy in spinal cord injury: Matched cohort analysis comparing drug classes, medical complications, and healthcare utilization metrics with 24-month follow-up.The journal of spinal cord medicine · 2025Article
- Role of voltage-gated CaJournal of neurophysiology · 2025Article
- Effects of Opioid Use Duration on Complications and Healthcare Utilization and Costs in Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2025Article
- Potentially harmful drug-drug interactions in the therapeutic regimens of persons with spinal cord injury.The journal of spinal cord medicine · 2024Observational
- Self-Reported Prescription Opioid Use Among Participants with Chronic Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2024Article
- Prescribing patterns for treating common complications of spinal cord injury.The journal of spinal cord medicine · 2023Observational
- Using Risk Scores to Estimate Lower Extremity Fragility Fracture Risk among Individuals with Chronic Spinal Cord Injury: A Preliminary Model.Topics in spinal cord injury rehabilitation · 2023Article
- Opioid Dependence and Associated Health Care Utilization and Cost in Traumatic Spinal Cord Injury Population: Analysis Using Marketscan Database.Topics in spinal cord injury rehabilitation · 2023Article
- Article
- Prescribing for common complications of spinal cord injury.Canadian family physician Medecin de famille canadien · 2022Article
- Risk Factors and Consequences of Lower Extremity Fracture Nonunions in Veterans With Spinal Cord Injury.JBMR plus · 2022Article
- Management of Mental Health Disorders, Substance Use Disorders, and Suicide in Adults with Spinal Cord Injury.The journal of spinal cord medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the association between opioid use and lower extremity fracture risk in men with spinal cord injury (SCI).
designRetrospective cohort study.
settingVeterans Affairs Healthcare System.
participantsIn total, 7447 male Veterans with a history of a traumatic SCI identified from the Veterans Affairs (VA) Spinal Cord Dysfunction Registry (SCD) from September 2002 through October 2007 and followed through October 2010. OUTCOME MEASURES: Incident lower extremity fractures by use of opioids.
resultsIn individuals identified from the VA SCD Registry 2002-2007, opioid use was quite common, with approximately 70% of the cohort having received a prescription for an opioid. Overall, there were 892 incident lower extremity fractures over the time period of this study (597 fractures in the opioid users and 295 fractures in the non-opioid users). After adjusting for covariates, there was a statistically significant relationship between opioid use and increased risk for lower extremity fractures (hazard ratio 1.82 (95% confidence interval 1.59-2.09)). Shorter duration of use (<6 months) and higher doses were positively related to fracture risk (P < 0.0001).
conclusionsOpioid use is quite common in SCI and is associated with an increased risk for lower extremity fractures. Careful attention to fracture prevention is warranted in patients with SCI, particularly upon initiation of an opioid prescription and when higher doses are used.
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