ArticleImmunity2013
Specific gut commensal flora locally alters T cell tuning to endogenous ligands.
Article in Immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Segmented filamentous bacteria are worldwide human gut commensals.Nature communications · 2026Article
- The dual role of T cells in solid organ transplant rejection and immune tolerance.Frontiers in immunology · 2026Review
- The Role of the Gut Microbiome in Cancer Immunotherapy: Current Knowledge and Future Directions.Cancers · 2023Review
- NK cells contribute to reovirus-induced IFN responses and loss of tolerance to dietary antigen.JCI insight · 2022Article
- Commensal gut bacterium critically regulates alveolar bone homeostasis.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- Dietary Regulation of the Crosstalk between Gut Microbiome and Immune Response in Inflammatory Bowel Disease.Foods (Basel, Switzerland) · 2021Review
- Article
- Microbiota-Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis.Nature reviews. Rheumatology · 2018Review
- Host-microbiota interplay in mediating immune disorders.Annals of the New York Academy of Sciences · 2018Review
- Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria.Trends in biochemical sciences · 2017Review
- Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis.Microbiome · 2017Article
- Role of intestinal microbiota and metabolites on gut homeostasis and human diseases.BMC immunology · 2017Review
- Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella histicola in Humanized Mice.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks.Gut · 2015Article
- Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site.Immunity · 2015Article
- Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1 mice.Clinical and experimental immunology · 2015Article
- Article
- The interplay between the intestinal microbiota and the immune system.Clinics and research in hepatology and gastroenterology · 2015Review
- The Tumor Macroenvironment: Cancer-Promoting Networks Beyond Tumor Beds.Advances in cancer research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Differences in gut commensal flora can dramatically influence autoimmune responses, but the mechanisms behind this are still unclear. We report, in a Th1-cell-driven murine model of autoimmune arthritis, that specific gut commensals, such as segmented filamentous bacteria, have the ability to modulate the activation threshold of self-reactive T cells. In the local microenvironment of gut-associated lymphoid tissues, inflammatory cytokines elicited by the commensal flora dynamically enhanced the antigen responsiveness of T cells that were otherwise tuned down to a systemic self-antigen. Together with subtle differences in early lineage differentiation, this ultimately led to an enhanced recruitment of pathogenic Th1 cells and the development of a more severe form of autoimmune arthritis. These findings define a key role for the gut commensal flora in sustaining ongoing autoimmune responses through the local fine tuning of T-cell-receptor-proximal activation events in autoreactive T cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.