Evidence map›Paper›PMID 23808800›Full record

Trial reportClinical transplantation

De novo malignancy post-liver transplantation: a single center, population controlled study.

Hemant Chatrath, Kenneth Berman, Raj Vuppalanchi, James Slaven, Paul Kwo, A Joseph Tector, Naga Chalasani, Marwan Ghabril

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. World journal of gastroenterology · 2019
    Pooled it
  3. Incidence, screening, and management ofWorld journal of transplantation · 2025
    Review
  4. Risk Factors of All-Causes Mortality andArchives of Iranian medicine · 2025
    Article
  5. Complications of liver transplant.Abdominal radiology (New York) · 2021
    Review
  6. Observational
  7. Review
  8. Article
  9. Review
  10. Melanoma Risk and Survival among Organ Transplant Recipients.The Journal of investigative dermatology · 2015
    Article
  11. Review
  12. Female gender in the setting of liver transplantation.World journal of transplantation · 2014
    Review
  13. Article
  14. Liver transplantation: immunosuppression and oncology.Current opinion in organ transplantation · 2014
    Review
  15. Article
  16. Extrahepatic Malignancies and Liver Transplantation: Current Status.Journal of clinical and experimental hepatology
    Review
  17. Dental and ENT Evaluation Before Liver Transplantation.Journal of clinical and experimental hepatology
    Review
  18. Long-term Management of the Adult Liver Transplantation Recipients.Journal of clinical and experimental hepatology
    Review
  19. Incidence ofSaudi journal of medicine & medical sciences
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hemant ChatrathInternal Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Kenneth Berman
Raj Vuppalanchi
James Slaven
Paul Kwo
A Joseph Tector
Naga Chalasani
Marwan Ghabril
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

Patient-Oriented Research of Liver DiseaseK24DK069290 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHALASANI, NAGA P · 2005 to 2014
$1.4M
NIDDK NIH HHS K24 DK069290NIDDK NIH HHS K25 DK069290
6 · The paper itself

Abstract

backgroundWith the growing numbers of liver transplant recipients, it is increasingly important to understand the risks of de novo malignancy after liver transplantation.

aimTo characterize the incidence of de novo malignancy after liver transplantation compared with a control non-transplant population.

methodsWe studied 534 Indiana state residents undergoing liver transplantation at our center between 1997 and 2004, followed through August 2010. The incidence and predictors of malignancy were determined. The standardized incidence ratio (SIR) of cancer in our cohort was compared with age-, gender-, and period-matched state population using the Indiana State Cancer Registry.

resultsAfter a mean follow-up of 5.7 ± 3.2 yr, 73 patients (13.7%) developed 80 cancers, with five- and 10-yr incidence rates of 11.7% and 24.8%, respectively. These included 24 (30%) skin, 16 (20%) hematologic, and 40 (50%) solid tumors. The most common solid cancers were aerodigestive. Compared with matched state population, liver transplant recipients had significantly higher incidence of all cancers (SIR: 3.1, 95% CI [Confidence interval]: 2.9-3.2), skin (melanoma) (SIR: 5.8, 95% CI: 4.7-7.0), hematologic (SIR: 7.1, 95% CI: 6.3-8.0), and solid (SIR: 2.7, 95% CI: 2.5-2.8) tumors.

conclusionThere is a significantly increased risk of de novo malignancies after liver transplantation, highlighting the need for surveillance strategies in this population.

Indexed as

Postoperative ComplicationsAdolescentAdultFemaleFollow-Up StudiesHumansIncidenceIndianaKidney TransplantationLiver FailureLiver TransplantationMaleMiddle AgedNeoplasmsPrognosisRetrospective Studiesde novoliver transplantationmalignancypopulation control studystandardized incidence ratio

Identifiers

PMID23808800
PMCPMC3740024
OpenAlexW2094414041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.