ArticleAlcoholism, clinical and experimental research2013
Circadian genes differentially affect tolerance to ethanol in Drosophila.
Article in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Diet Modification Alters Repeated Exposure Ethanol Tolerance Development.microPublication biology · 2026Article
- A Brief Overview of Ethanol Tolerance and Its Potential Association with Circadian Rhythm inInternational journal of molecular sciences · 2024Review
- Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models.International journal of molecular sciences · 2024Review
- Alcohol sensitivity and tolerance encoding in sleep regulatory circadian neurons in Drosophila.Addiction biology · 2023Article
- Alcohol tolerance encoding in sleep regulatory circadian neurons in Drosophila.bioRxiv : the preprint server for biology · 2023Article
- A simple high-throughput method for automated detection of Drosophila melanogaster light-dependent behaviours.BMC biology · 2022Article
- A Non-Nuclear NF-κB Modulates Alcohol Sensitivity But Not Immunity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Repeated ethanol intoxications of Drosophila melanogaster adults increases the resistance to ethanol of their progeny.Alcoholism, clinical and experimental research · 2021Article
- Flying Together:International journal of molecular sciences · 2020Review
- High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster.Journal of visualized experiments : JoVE · 2020Article
- F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol-Induced Behaviors in Drosophila.Alcoholism, clinical and experimental research · 2019Article
- Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies inFrontiers in physiology · 2018Review
- Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder.Frontiers in physiology · 2018Review
- A Fly's Eye View of Natural and Drug Reward.Frontiers in physiology · 2018Review
- Genetics and genomics of alcohol responses in Drosophila.Neuropharmacology · 2017Review
- Review
- I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Mutations in the circadian gene period alter behavioral and biochemical responses to ethanol in Drosophila.Behavioural brain research · 2016Article
- Shared neurocircuitry underlying feeding and drugs of abuse in Drosophila.Biomedical journal · 2015Review
- Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2015Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is a strong relationship between circadian rhythms and ethanol (EtOH) responses. EtOH consumption has been shown to disrupt physiological and behavioral circadian rhythms in mammals (Alcohol Clin Exp Res 2005b, 29, 1550). The Drosophila central circadian pacemaker is composed of proteins encoded by the per, tim, cyc, and Clk genes. Using Drosophila mutant analysis, we asked whether these central components of the circadian clock make the equivalent contribution toward EtOH tolerance and whether rhythmicity itself is necessary for tolerance.
methodsWe tested flies carrying mutations in core clock genes for the capacity to acquire EtOH tolerance. Tolerance was assayed by comparing the sedation curves of populations during their first and second sedation. Animals that had acquired tolerance sedated more slowly. Movement was also monitored as the flies breathe the EtOH vapor to determine if other facets of the EtOH response were affected by the mutations. Gas chromatography was used to measure internal EtOH concentration. Constant light was used to nongenetically destabilize the PER and TIM proteins.
resultsA group of circadian mutations, all of which eliminate circadian rhythms, do not disrupt tolerance identically. Mutations in per, tim, and cyc completely block tolerance. However, a mutation in Clk does not interfere with tolerance. Constant light also disrupts the capacity to acquire tolerance. These lines did not differ in EtOH absorption.
conclusionsMutations affecting different parts of the intracellular circadian clock can block the capacity to acquire rapid EtOH tolerance. However, the role of circadian genes in EtOH tolerance is independent of their role in producing circadian rhythmicity. The interference in the capacity to acquire EtOH tolerance by some circadian mutations is not merely a downstream effect of a nonfunctional circadian clock; instead, these circadian genes play an independent role in EtOH tolerance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.