ArticleJournal of child psychology and psychiatry, and allied disciplines2013
Candidate gene associations with withdrawn behavior.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients.Biomedicines · 2022Article
- Genetic analysis of suicide: a sample study in Tuscany (Central Italy).Forensic sciences research · 2022Article
- Withdrawn Behavior in Preschool: Implications for Emotion Knowledge and Broader Emotional Competence.Frontiers in psychology · 2022Article
- Molecular laterality encodes stress susceptibility in the medial prefrontal cortex.Molecular brain · 2021Article
- The therapeutic and protective effects of bee pollen against prenatal methylmercury induced neurotoxicity in rat pups.Metabolic brain disease · 2020Article
- Association of rs4680Frontiers in psychiatry · 2019Article
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Article
- Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature.Amino acids · 2017Review
- Therapeutic potency of bee pollen against biochemical autistic features induced through acute and sub-acute neurotoxicity of orally administered propionic acid.BMC complementary and alternative medicine · 2016Article
- Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains.Neuropharmacology · 2015Article
- Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.PloS one · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSocial withdrawal is a core neuropsychiatric phenomenon in developmental psychopathology. Its presence predicts psychopathology across many domains, including depression, psychosis, autism, anxiety, and suicide. Withdrawn behavior is highly heritable, persistent, and characteristically worsens without intervention. To date, few studies have successfully identified genetic associations with withdrawn behavior, despite the abundance of evidence of its heritability. This may be due to reliance of categorical over dimensional measures of the behaviorally inhibited phenotype. The aim of this study is to identify associations between known psychiatric candidate genes and a dimensionally derived measure of withdrawn behavior.
methodsGenetic information was collected on 20 single-nucleotide polymorphisms (SNPs) from a custom-designed SNP chip and TAQMAN arrays of 4 variable number of tandem repeat (VNTR) genes for 551 individuals from 187 families. Linear mixed modeling was employed to examine the relationship between genotypes of interest and Child Behavior Checklist (CBCL) Withdrawn Behavior Subscale Score (WBS) while controlling for gender and age through multiple linear regressions.
resultsWithdrawn behavior was highly associated with polymorphism rs6314 of the serotonin receptor 2A (HTR2A) [p = .009, estimate = 0.310 (bootstrap 95% CI 0.155-0.448), bootstrap p = .001] and rs1800544 of the alpha 2-adrenergic (ADRA2A) [p = .001, estimate = -0.310 (bootstrap 95% CI -0.479 to -0.126), bootstrap p = .001] genes after correction for gender and age. The association between withdrawn behavior and ADRA2A was stronger for younger children.
conclusionsHTR2A and ADRA2A genes are associated with withdrawn behavior. This reinforces the role of catecholaminergic genes in the heritability of withdrawn behavior.
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