ArticleAnnals of human genetics2013
Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.
Article in Annals of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.Atherosclerosis · 2014Pooled it
- Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors.GeroScience · 2025Article
- Fatty acid desaturase genetic variations in heart failure and cardiovascular disease.American heart journal plus : cardiology research and practice · 2025Review
- Article
- Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study.Nutrition & metabolism · 2022Article
- Genome-wide association study of circulating interleukin 6 levels identifies novel loci.Human molecular genetics · 2021Article
- Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.International journal of epidemiology · 2017Article
- Association of the ST3GAL4 rs11220462 polymorphism and serum lipid levels in the Mulao and Han populations.Lipids in health and disease · 2014Article
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Authors and funding
31 authors.
Funding
Abstract
Numerous common genetic variants that influence plasma high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride distributions have been identified via genome-wide association studies (GWAS). However, whether or not these associations are age-dependent has largely been overlooked. We conducted an association study and meta-analysis in more than 22,000 European Americans between 49 previously identified GWAS variants and the three lipid traits, stratified by age (males: <50 or ≥50 years of age; females: pre- or postmenopausal). For each variant, a test of heterogeneity was performed between the two age strata and significant Phet values were used as evidence of age-specific genetic effects. We identified seven associations in females and eight in males that displayed suggestive heterogeneity by age (Phet < 0.05). The association between rs174547 (FADS1) and LDL-C in males displayed the most evidence for heterogeneity between age groups (Phet = 1.74E-03, I(2) = 89.8), with a significant association in older males (P = 1.39E-06) but not younger males (P = 0.99). However, none of the suggestive modifying effects survived adjustment for multiple testing, highlighting the challenges of identifying modifiers of modest SNP-trait associations despite large sample sizes.
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