ArticleInternational journal of oral science2013
Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium.
Article in International journal of oral science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 69 citations in OpenAlex.
- FAM20A Deficiency Drives Transcriptomic Dysregulation and Functional Impairment in Gingival Fibroblasts.Cell proliferation · 2026Article
- Abnormal dental follicle cells: A crucial determinant in tooth eruption disorders (Review).Molecular medicine reports · 2024Review
- Fibroblast growth factor signalling regulates the development of tooth root.Journal of anatomy · 2024Article
- A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning.International journal of oral science · 2024Article
- Ablation of FAM20C caused short root defects via suppressing the BMP signaling pathway in mice.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2023Article
- Loss of Stat3 in OsterixCell & bioscience · 2023Article
- BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications.Frontiers in cell and developmental biology · 2023Review
- Between a rock and a hard place: Regulation of mineralization in the periodontium.Genesis (New York, N.Y. : 2000) · 2022Review
- Article
- Cell dynamics in Hertwig's epithelial root sheath are regulated by β-catenin activity during tooth root development.Journal of cellular physiology · 2021Article
- BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation.Cell death & disease · 2021Article
- Unveiling diversity of stem cells in dental pulp and apical papilla using mouse genetic models: a literature review.Cell and tissue research · 2021Review
- Comparison of osteogenic and dentinogenic potentials of mice incisor and molar pulps in vitro.Archives of oral biology · 2020Article
- Mesenchymal Progenitor Regulation of Tooth Eruption: A View from PTHrP.Journal of dental research · 2020Article
- Article
- Dentinogenesis and Tooth-Alveolar Bone Complex Defects inStem cells and development · 2019Article
- Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.Journal of molecular histology · 2019Article
- IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development.Cell death & disease · 2019Article
- [The role of bone morphogenetic protein signaling pathway in tooth root development].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Review
- The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis.Archives of oral biology · 2018Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7(+) (Osterix(+)) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA(+) cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKO(Sp7-Cre-EGFP). Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKO(Sp7-Cre-EGFP). These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation.
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