ArticleEuropean journal of histochemistry : EJH2013
An ex vivo study on immunohistochemical localization of MMP-7 and MMP-9 in temporomandibular joint discs with internal derangement.
Article in European journal of histochemistry : EJH, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Matrix metalloproteinase 14 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Trial
- Immunohistochemical analysis of matrix metalloproteinase-13 in human caries dentin.European journal of histochemistry : EJH · 2014Trial
- Decoding Temporomandibular Disorders: Identifying Stage-Specific and Functional Patterns in the Articular Disc.Stem cell reviews and reports · 2026Review
- Temporomandibular joint degeneration arises spontaneously in STR/ort mice and is prevented by targeted aggrecanase inhibition.Osteoarthritis and cartilage open · 2025Article
- Histological and Immunohistochemical Insights into Disc Perforation in the Temporomandibular Joint: A Case Report.Journal of functional morphology and kinesiology · 2025Article
- Pregnancy related factors and temporomandibular disorders evaluated through the diagnostic criteria for temporomandibular disorders (DC/TMD) axis II: a cross sectional study.BMC oral health · 2024Article
- Immunohistochemical Markers of Temporomandibular Disorders: A Review of the Literature.Journal of clinical medicine · 2023Review
- Quality Comparison of Decellularized Omentum Prepared by Different Protocols for Tissue Engineering Applications.Cell journal · 2022Article
- Quercetin inhibits fibroblasts proliferation and reduces surgery-induced epidural fibrosis via the autophagy-mediated PI3K/Akt/mTOR pathway.Bioengineered · 2022Article
- Class II Skeletal Malocclusion and Prevalence of Temporomandibular Disorders. An Epidemiological Pilot Study on Growing Subjects.Journal of functional morphology and kinesiology · 2021Article
- Articular Disc of a Human Temporomandibular Joint: Evaluation through Light Microscopy, Immunofluorescence and Scanning Electron Microscopy.Journal of functional morphology and kinesiology · 2021Article
- The relationship between abnormal Core binding factor-β expression in human cartilage and osteoarthritis.BMC musculoskeletal disorders · 2021Article
- Histological and Immunofluorescence Study of Discal Ligaments in Human Temporomandibular Joint.Journal of functional morphology and kinesiology · 2020Article
- Craniomandibular Disorders in Pregnant Women: An Epidemiological Survey.Journal of functional morphology and kinesiology · 2020Article
- MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction.European journal of histochemistry : EJH · 2020Article
- Estrogen Selectively Enhances TMJ Disc but Not Knee Meniscus Matrix Loss.Journal of dental research · 2019Article
- miRNA-155 expression and role in pathogenesis in spinal tuberculosis-induced intervertebral disc destruction.Experimental and therapeutic medicine · 2019Article
- 17β-estradiol Induces MMP-9 and MMP-13 in TMJ Fibrochondrocytes via Estrogen Receptor α.Journal of dental research · 2018Article
- Low-level laser therapy stimulates tissue repair and reduces the extracellular matrix degradation in rats with induced arthritis in the temporomandibular joint.Lasers in medical science · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Internal derangement (ID) is among the most common disorders of the temporomandibular joint (TMJ). Previous research by our group highlighted a correlation between apoptosis and TMJ ID. Metalloproteinases (MMP)-7 and -9 have been shown to play an important role in extracellular matrix ECM) homeostasis and, through it, in joint disc remodelling. The immunohistochemical expression of MMP-7 and -9 was investigated in discs from patients with TMJ ID and from healthy donors and compared with the degree of histological tissue degeneration. The collagen fibre arrangement in pathological discs exhibited varying degrees of disruption. New vessels were consistently detected; endothelial cells from these vessels were immunolabelled with both MMP-7 and MMP-9. More or less intense MMP-7 and MMP-9 immunolabelling was detected in the cytoplasm of disc cells from all patients. MMP-7 and MMP-9 immunostaining was significantly different between pathological and normal discs and correlated with the extent of histopathological degeneration. MMP-7 and MMP-9 upregulation in discs from patients with TMJ ID demonstrates their involvement in disc damage in this disorder. A greater understanding of these processes could help identify ways to curb MMP overproduction without affecting their tissue remodelling action. The design of specific inhibitors for these MMPs would not only help to gain insights into the biological roles of MMPs, but would also aid in developing therapeutic interventions for diseases associated with abnormal ECM degradation.
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