ArticleAIDS (London, England)2013
The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s.
Article in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 2 of them syntheses that pooled it.
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94 citing papers in PubMed, 2 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Defining HIV-1 transmission clusters based on sequence data.AIDS (London, England) · 2017Pooled it
- Prevalence of different HIV-1 subtypes in sexual transmission in China: a systematic review and meta-analysis.Epidemiology and infection · 2016Pooled it
- Molecular footprints of a traveling epidemic: CRF01_AE-cluster 5 (01_C5) might spread across Northeast and South China via middle-aged MSM.Emerging microbes & infections · 2026Article
- Co-receptor usage in distinct phylogenetic clusters of HIV-1 CRF01_AE is associated with differential immune reconstitution after antiretroviral therapy.Microbiology spectrum · 2026Article
- Pervasive HIV recombination limits the utility of circulating recombinant form nomenclature.PLoS pathogens · 2026Article
- Emergence of newly reported HIV-1 recombinants CRF120_0107 and CRF149_01B in Guangxi Zhuang Autonomous Region, China: Molecular evidence and public health challenges.Biosafety and health · 2026Article
- Molecular transmission network reveals CRF08_BC-driven clusters of HIV-1 among low-education older adults linked to female sex workers in Taizhou, China.Frontiers in microbiology · 2026Article
- Molecular transmission network and drug resistance analysis of 404 HIV-1 cases infected through commercial heterosexual contact (2020-2024).Frontiers in public health · 2026Article
- Dynamic transmission and evolutionary analysis of the HIV-1 subtype CRF01_AE pol region in Ningxia, China.PloS one · 2026Article
- Global spread and evolutionary trajectories of HIV-1 CRF01_AE: Insights from phylogenetic analysis.PloS one · 2026Article
- Divergent transmission dynamics and drug resistance evolution of HIV-1 CRF01_AE and CRF07_BC in Tianjin, China (2013-2022).Virology journal · 2025Article
- Characterization of the HIV-1 molecular network in a middle-aged population aged 50 years and older in a City in Southern Sichuan, China.Scientific reports · 2025Article
- Genetic characterization of a novel HIV-1 circulating recombinant form (CRF162_cpx) involving CRF01_AE, CRF07_BC and subtype B in Guangdong, China.Virus genes · 2025Article
- PacBio high-fidelity near full-length genome sequencing for HIV-1 quasispecies: methodological framework and validation.Frontiers in microbiology · 2025Article
- National and Regional Molecular Epidemiology of HIV-1 - China, 2004-2023.China CDC weekly · 2024Article
- Article
- Identification of the Near Full-Length Genome of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant in Hebei Province, China.AIDS research and human retroviruses · 2024Article
- Near-full-length genome analysis of two novel HIV second recombinant forms in Hebei, China.Archives of virology · 2024Article
- Distinct genetic clusters in HIV-1 CRF01_AE-infected patients induced variable degrees of CD4mBio · 2024Article
- Distinct Clusters of HIV-1 CRF01_AE in Zhejiang, China: High-Risk Transmission Cluster 4 Requires Heightened Surveillance.Infection and drug resistance · 2024Article
34 more citing papers are in PubMed but not listed here.
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12 authors at 5 institutions in 4 countries.
Funding
Abstract
objectivesWe sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China.
methodsAvailable HIV-1 CRF01_AE samples indentified in national molecular epidemiologic surveys were used to generate near full-length genome (NFLG) sequences. The new and globally available CRF01_AE NFLG sequences were subjected to phylogenetic and Bayesian molecular clock analyses, and combined with epidemiologic data to elucidate the history of CRF01_AE transmission in China.
resultsWe generated 75 new CRF01_AE NFLG sequences from various risk populations covering all major CRF01_AE epidemic regions in China. Seven distinct phylogenetic clusters of CRF01_AE were identified. Clusters 1, 2 and 3 were prevalent among heterosexuals and IDUs in southern and southwestern provinces. Clusters 4 and 5 were found primarily among MSM in major northern cities. Clusters 6 and 7 were only detected among heterosexuals in two southeast and southwest provinces. Molecular clock analysis indicated that all CRF01_AE clusters were introduced from Southeast Asia in the 1990s, coinciding with the peak of Thailand's HIV epidemic and the initiation of China's free overseas travel policy for their citizens, which started with Thailand as the first destination country.
conclusionChina's HIV-1 epidemic of sexual transmissions, was initiated by multilineages of CRF01_AE strains, in contrast to the mono-lineage epidemic of B' strain in former plasma donors and IDUs. Our study underscores the difficulty in controlling HIV-1 sexual transmission compared with parenteral transmission.
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