Evidence map›Paper›PMID 23807026›Full record

ArticleRNA biology2013

Quantitative trait locus mapping identifies REME2, a PPR-DYW protein required for editing of specific C targets in Arabidopsis mitochondria.

Stéphane Bentolila, Arianne M Babina, Arnaud Germain, Maureen R Hanson

Abstract read
In one paragraph

Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Two interacting PPR proteins are major Arabidopsis editing factors in plastid and mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stéphane BentolilaDepartment of Molecular Biology and Genetics; Cornell University; Ithaca, NY USA.
Arianne M BabinaDepartment of Molecular Biology and Genetics; Cornell University; Ithaca, NY USA.
Arnaud GermainDepartment of Molecular Biology and Genetics; Cornell University; Ithaca, NY USA.
Maureen R HansonDepartment of Molecular Biology and Genetics; Cornell University; Ithaca, NY USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeted RNA editing by C-to-U alteration occurs at hundreds of sites in the mitochondrial transcriptome of flowering plants. By using natural variation and positional cloning on a population of Arabidopsis recombinant inbred lines between the ecotypes Col and Ler, we found that two of these occurrences involve the Arabidopsis PPR-DYW protein REME2 (Required for Efficiency of Mitochondrial Editing2). The analysis of a knockdown mutant along with silenced tissues confirms the specificity of REME2 for both sites located in mitochondrial ribosomal protein genes (rps3-1534 and rps4-175). The conservation level of both cis elements is relatively high, as is the amino acid conservation among flowering plants for both genes in that location, underlining the importance of these editing events and REME2.

Indexed as

RNA EditingAmino Acid SequenceArabidopsisArabidopsis ProteinsDNA, BacterialGene Expression Regulation, PlantGene Knockdown TechniquesMitochondriaMolecular Sequence DataPlant ProteinsPolymorphism, Single NucleotideQuantitative Trait LociRegulatory Sequences, Nucleic AcidRibosomal ProteinsRNA-Binding ProteinsSequence Homology, Amino AcidArabidopsis ProteinsDNA, BacterialPlant ProteinsREME2 protein, ArabidopsisRibosomal ProteinsRNA-Binding ProteinsRPS3 protein, Arabidopsisrps4 protein, plantT-DNAplant mitochondriaQTL mappingRPS3RPS4virus-induced gene silencing

Identifiers

PMID23807026
PMCPMC3858435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.