Trial reportDrug and alcohol dependence2013
Methamphetamine dependent individuals show attenuated brain response to pleasant interoceptive stimuli.
Trial report in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Building the bodily self-awareness: Evidence for the convergence between interoceptive and exteroceptive information in a multilevel kernel density analysis study.Human brain mapping · 2020Pooled it
- Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron · 2018Pooled it
- Enhancing interoceptive awareness in chronic pain and opioid misuse via mindfulness-oriented recovery enhancement.Drug and alcohol dependence · 2025Trial
- Mesocorticolimbic Dopamine-Reward Tract Alterations and the 'Dark Side' of Methamphetamine Addiction.Addiction biology · 2026Article
- Context-dependent asymmetries in intertemporal decision-making: a comparative study of substance use disorder and control groups.Substance abuse treatment, prevention, and policy · 2026Article
- Atypical contributions of reward decisions to momentary mood in individuals with methamphetamine use disorder.BMC psychiatry · 2025Article
- Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward.Journal of psychopharmacology (Oxford, England) · 2024Article
- Early-onset smoking theory of compulsivity development: a neurocognitive model for the development of compulsive tobacco smoking.Frontiers in psychiatry · 2023Article
- Mindfulness-Based Interventions for the Treatment of Aberrant Interoceptive Processing in Substance Use Disorders.Brain sciences · 2022Review
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Decreased reward-related brain function prospectively predicts increased substance use.Journal of abnormal psychology · 2021Article
- Interoceptive attention in opioid and stimulant use disorder.Addiction biology · 2020Article
- Increased anticipatory brain response to pleasant touch in women remitted from bulimia nervosa.Translational psychiatry · 2020Article
- Do Adolescents Use Substances to Relieve Uncomfortable Sensations? A Preliminary Examination of Negative Reinforcement among Adolescent Cannabis and Alcohol Users.Brain sciences · 2020Article
- Signatures of alcohol use in the structure and neurochemistry of insular cortex: a correlational study.Psychopharmacology · 2019Article
- Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women.NeuroImage. Clinical · 2019Article
- Neural hypersensitivity to pleasant touch in women remitted from anorexia nervosa.Translational psychiatry · 2018Article
- Tulsa 1000: a naturalistic study protocol for multilevel assessment and outcome prediction in a large psychiatric sample.BMJ open · 2018Observational
- Identification of the Features of Emotional Dysfunction in Female Individuals With Methamphetamine Use Disorder Measured by Musical Stimuli Modulated Startle Reflex.Frontiers in human neuroscience · 2018Article
- Lifestyle and neurodegeneration in midlife as expressed on functional magnetic resonance imaging: A systematic review.Alzheimer's & dementia (New York, N. Y.) · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundMechano-receptive C-fiber (MR-CF) stimulation via slow stroking of C-fiber rich skin areas can be used to probe the relationship between reward and interoception. Individuals with substance use disorders show impaired reward processing, and dysfunctional interoceptive processing of MR-CF may contribute to this dysfunction. This study predicted that methamphetamine dependent (MD) individuals would exhibit altered responses to MR-CF stimulation in brain regions important for interoception.
methodsRecently abstinent MD (n=25) and comparison (CTL, n=17) subjects received a pleasant interoceptive stimulus ("Soft Touch" consisting of a slow brush stroke) to the palm or forearm during functional magnetic resonance imaging. Subjects were provided with cues signaling stimulation to examine anticipatory and stimulus-related processing. Subjective responses were measured using visual analog scales (VAS).
resultsGroups were similar on behavioral performance and ratings of the interoceptive stimuli, yet MD exhibited lower anterior insula, dorsal striatum, and thalamus activation than CTL, across anticipation and soft touch conditions. The lower the anterior insula activation, the faster the reaction time across conditions in MD, whereas the opposite pattern was evident in CTL. Striatal activation in MD was greater than CTL during anticipation, but lower during soft touch. Greater striatal attenuation was associated with higher VAS pleasantness ratings of soft touch.
conclusionsMD expend fewer brain processing resources during soft touch, a form of positively-valenced interoceptive stimuli, in brain areas that are important for both interoception and reward. Future studies will ascertain if sustained abstinence from methamphetamine use can normalize aberrant neural interoceptive processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.