ArticleMicrovascular research2013
Automated segmentation and fractal analysis of high-resolution non-invasive capillary perfusion maps of the human retina.
Article in Microvascular research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker.Frontiers in neuroscience · 2020Pooled it
- Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults.Investigative ophthalmology & visual science · 2025Trial
- Decreased retinal capillary density as a beneficial response to 24-week high-speed circuit resistant training in healthy older adults.Microvascular research · 2024Trial
- Lid Wiper Microvascular Responses as an Indicator of Contact Lens Discomfort.American journal of ophthalmology · 2016Trial
- Reduced Retinal Perfusion With Preserved Microvascular Network Density in Early Alzheimer's Disease: A Multimodal Imaging Study.Translational vision science & technology · 2026Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- OCTA evaluates changes in retinal microvasculature in renal hypertension patients.Scientific reports · 2024Article
- Assessment of Blood Flow Velocity in Retinal Vasculitis Using the Retinal Function Imager-A Pilot Study.Journal of clinical medicine · 2024Article
- Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies.Nutrients · 2022Review
- Macular and Optic Nerve Microvascular Alteration in Relation to Axial Length, by Optical Coherence Tomography Angiography (OCTA).Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Article
- Advances in retina imaging as potential biomarkers for early diagnosis of Alzheimer's disease.Translational neurodegeneration · 2021Review
- Visual Function and Disability Are Associated with Increased Retinal Volumetric Vessel Density in Patients with Multiple Sclerosis.American journal of ophthalmology · 2020Article
- Retinal oximetry and fractal analysis of capillary maps in sickle cell disease patients and matched healthy volunteers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Observational
- Inter-visit measurement variability of conjunctival vasculature and circulation in habitual contact lens wearers and non-lens wearers.Eye and vision (London, England) · 2019Article
- Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series.Eye and vision (London, England) · 2019Article
- Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2018Article
- Retinal tissue hypoperfusion in patients with clinical Alzheimer's disease.Eye and vision (London, England) · 2018Article
- Retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes.Eye and vision (London, England) · 2018Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The retina provides a window to study the pathophysiology of cerebrovascular diseases. Pathological retinal microvascular changes may reflect microangiopathic processes in the brain. Recent advances in optical imaging techniques have enabled the imaging of the retinal microvasculature at the capillary level, and the generation of high-resolution, non-invasive capillary perfusion maps (nCPMs) with the Retinal Function Imager (RFI). However, the lack of quantitative analyses of the nCPMs may limit the wider application of the method in clinical research. The goal of this project was to demonstrate the feasibility of automated segmentation and fractal analysis of nCPMs. We took two nCPMs of each subject in a group of 6 healthy volunteers and used our segmentation algorithm to do the automated segmentation for monofractal and multifractal analyses. The monofractal dimension was 1.885±0.020, and the multifractal dimension was 1.876±0.010 (P=0.108). The coefficient of repeatability was 0.070 for monofractal analysis and 0.026 for multifractal analysis. This study demonstrated that the automatic segmentation of nCPMs is feasible for fractal analyses. Both monofractal and multifractal analyses yielded similar results. The quantitative analyses of microvasculature at the capillary level may open up a new era for studying microvascular diseases such as cerebral small vessel disease.
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