Evidence map›Paper›PMID 23806439›Full record

ReviewNeuroscience and biobehavioral reviews2013

Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis.

Wendy J Lynch, Alexis B Peterson, Victoria Sanchez, Jean Abel, Mark A Smith

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  11. Effect of Eight-Month Exercise Intervention on Bone Outcomes of Young Opioid-Dependent Women.International journal of environmental research and public health · 2021
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  13. Reinforcing exercise to improve drug abuse treatment outcomes: A randomized controlled study in a substance use disorder outpatient treatment setting.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
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  15. Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wendy J LynchDepartment of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA. Electronic address: wlynch@virginia.edu.
Alexis B Peterson
Victoria Sanchez
Jean Abel
Mark A Smith

Funding

Dopaminergic and Glutamatergic Mechanisms of Cocaine Addiction: Sex DifferencesR01DA024716 · NIDA · UNIVERSITY OF VIRGINIA · PI Wendy Jean Lynch · 2008 to 2026
$6.1M
Social Influences on Drug-Seeking BehaviorR01DA031725 · NIDA · DAVIDSON COLLEGE · PI SMITH, MARK A · 2012 to 2022
$3.1M
Rat Models of Alcohol Dependence for Evaluating Combined Medication EffectsR01AA016554 · NIAAA · UNIVERSITY OF VIRGINIA · PI LYNCH, WENDY JEAN · 2008 to 2012
$1.6M
Physical Activity and Substance AbuseR01DA027485 · NIDA · DAVIDSON COLLEGE · PI SMITH, MARK A · 2009 to 2013
$943k
NIAAA NIH HHS R01 AA016554NIAAA NIH HHS R01-AA016554NIDA NIH HHS R01 DA024716NIDA NIH HHS R01-DA024716NIDA NIH HHS R01-DA024716-S1NIDA NIH HHS R01 DA027485NIDA NIH HHS R01-DA027485NIDA NIH HHS R01 DA031725
6 · The paper itself

Abstract

Physical activity, and specifically exercise, has been suggested as a potential treatment for drug addiction. In this review, we discuss clinical and preclinical evidence for the efficacy of exercise at different phases of the addiction process. Potential neurobiological mechanisms are also discussed focusing on interactions with dopaminergic and glutamatergic signaling and chromatin remodeling in the reward pathway. While exercise generally produces an efficacious response, certain exercise conditions may be either ineffective or lead to detrimental effects depending on the level/type/timing of exercise exposure, the stage of addiction, the drug involved, and the subject population. During drug use initiation and withdrawal, its efficacy may be related to its ability to facilitate dopaminergic transmission, and once addiction develops, its efficacy may be related to its ability to normalize glutamatergic and dopaminergic signaling and reverse drug-induced changes in chromatin via epigenetic interactions with brain-derived neurotrophic factor (BDNF) in the reward pathway. We conclude with future directions, including the development of exercise-based interventions alone or as an adjunct to other strategies for treating drug addiction.

Indexed as

BrainBrain-Derived Neurotrophic FactorChromatin Assembly and DisassemblyDopamineExerciseExercise TherapyHumansSubstance-Related DisordersBrain-Derived Neurotrophic FactorDopamineAddictionAnimal modelsChromatinClinicalDopamineEpigeneticExerciseGlutamateNeurobiological mechanisms

Identifiers

PMID23806439
PMCPMC3788047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.