ArticlePlacenta2013
Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice.
Article in Placenta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Maternal and infant gut microbiome.iMeta · 2026Review
- Perturbations of the endometrial immune microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy.Seminars in immunopathology · 2025Review
- Treg cells promote decidual vascular remodeling and modulate uterine NK cells in pregnant mice.JCI insight · 2024Article
- A Framework for Understanding Maternal Immunity.Immunology and allergy clinics of North America · 2023Review
- Cytochrome P450 26A1 regulates the clusters and killing activity of NK cells during the peri-implantation period.Journal of cellular and molecular medicine · 2022Article
- Article
- Maternal natural killer cells at the intersection between reproduction and mucosal immunity.Mucosal immunology · 2021Review
- Epithelial membrane protein 2 (Emp2) modulates innate immune cell population recruitment at the maternal-fetal interface.Journal of reproductive immunology · 2021Article
- How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?Frontiers in immunology · 2021Review
- Obesity Challenge Drives Distinct Maternal Immune Response Changes in Normal Pregnant and Abortion-Prone Mouse Models.Frontiers in immunology · 2021Article
- Maternal Obesity and the Uterine Immune Cell Landscape: The Shaping Role of Inflammation.International journal of molecular sciences · 2020Review
- Cytokine-Based Generation of CD49aFrontiers in immunology · 2018Article
- Natural cytotoxicity receptor 1 in mouse uNK cell maturation and function.Mucosal immunology · 2017Article
- Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.Progress in lipid research · 2017Review
- Mapping out p38MAPK.American journal of reproductive immunology (New York, N.Y. : 1989) · 2017Review
- Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice.Frontiers in immunology · 2017Review
- The decidua-the maternal bed embracing the embryo-maintains the pregnancy.Seminars in immunopathology · 2016Review
- Maternal obesity drives functional alterations in uterine NK cells.JCI insight · 2016Article
- Composition, Development, and Function of Uterine Innate Lymphoid Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Leukocyte driven-decidual angiogenesis in early pregnancy.Cellular & molecular immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionActivated uterine natural killer (uNK) cells are abundant in early human and mouse decidual basalis. In mice, distinct uNK cell subsets support early endothelial tip cell induction, the pruning of new vessels and initiation of spiral arterial modification. While genetic studies indicate that NK/uNK cell activation via receptors recognizing Class I MHC-derived peptides promotes human pregnancy, roles for other activation receptors expressed by NK cells, such as the aryl hydrocarbon receptor (AHR) and natural cytotoxicity receptors (NCR) are undefined in human or mouse pregnancies.
methodsExpression of AHR and NCR1 (ortholog of human NKp46) by gestation day (gd)10.5 mouse uNK cell subsets was measured by quantitative real-time RT-PCR. Early implantation sites from mice lacking expression of either receptor were examined histologically.
resultsGd10.5 uNK cell subsets, separated by reactivity to Dolichos biflorus agglutinin lectin, differed in relative transcript abundance for Ahr and Ncr1. Quantitative histology revealed that, in comparison to C57BL/6 controls, implant sites from gd10.5 Ahr(-/-) and gd6.5-12.5 UkCa:B6.Ncr1(Gfp/Gfp) mice had normal uNK cell abundance but the uNK cells were smaller than normal and unable to trigger spiral arterial remodeling. Whole mount immunohistochemistry comparisons of viable, gd6.5-8.5 Ncr1(Gfp/Gfp) and C57BL/6 implant sites revealed deficits in implant site angiogenesis and conceptus growth in Ncr1(Gfp/Gfp). DISCUSSION: In mice, activation of AHR and of NCR1 by endogenous, as yet undefined ligands, contributes to uNK cell activation/maturation and angiogenic functions during early to mid-gestation pregnancy. MHC-independent activation of uNK cells also likely makes critical contributions to human pregnancy success.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.