ArticleBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2013
Early administration of oropharyngeal colostrum to extremely low birth weight infants.
Article in Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03393832 (Oral Care), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Oral Care: An Important Adjunctive Therapy to Improve Feeding Tolerance in Infants With Gastroschisis
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of oropharyngeal administration of colostrum on the incidence of necrotizing enterocolitis, late-onset sepsis, and death in preterm infants: a meta-analysis of RCTs.European journal of clinical nutrition · 2020Pooled it
- Oropharyngeal Colostrum for Preterm Infants: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Oropharyngeal colostrum in preventing mortality and morbidity in preterm infants.The Cochrane database of systematic reviews · 2018Pooled it
- The effect of oropharyngeal mother's milk on nutritional outcomes in preterm infants: a randomized controlled trial.BMC pediatrics · 2024Trial
- A randomized controlled trial of oropharyngeal therapy with mother's own milk for premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Oral Application of Colostrum and Mother's Own Milk in Preterm Infants-A Randomized, Controlled Trial.Indian journal of pediatrics · 2022Trial
- Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational age ≤ 32 weeks: a pilot single-center randomized controlled trial.International breastfeeding journal · 2021Trial
- Oropharyngeal Administration of Colostrum Increases Salivary Secretory IgA Levels in Very Low-Birth-Weight Infants.American journal of perinatology · 2017Trial
- Oral colostrum priming shortens hospitalization without changing the immunomicrobial milieu.Journal of perinatology : official journal of the California Perinatal Association · 2017Trial
- Buccal administration of human colostrum: impact on the oral microbiota of premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2016Trial
- Trial
- Oropharyngeal colostrum administration in neonates with gastroschisis: a randomized clinical trial.Critical care scienceTrial
- A Prospective-Retrospective Observational Cohort Study of Short-Term Health Outcomes of Preterm Very Low Birth Weight Infants Receiving Oropharyngeal Administration of Own Mother's Colostrum.Current therapeutic research, clinical and experimental · 2026Article
- Short-Term Outcomes of Early Oral Colostrum Administration in VLBW Neonates: An Open-Label Randomized Controlled Trial.Medical journal of the Islamic Republic of Iran · 2024Article
- Oropharyngeal Colostrum Administration in Premature Infants: Impact on Immune Status and Incidence of Common Morbidities.International journal of preventive medicine · 2024Article
- Nutrient Intake with Early Progressive Enteral Feeding and Growth of Very Low-Birth-Weight Newborns.Nutrients · 2022Article
- Oropharyngeal administration of mother's own milk influences levels of salivary sIgA in preterm infants fed by gastric tube.Scientific reports · 2022Article
- Leisure-time physical activity in Amazonian pregnant women and offspring birth weight: A prospective cohort study.PloS one · 2022Article
- Colostrum Therapy for Human Gastrointestinal Health and Disease.Nutrients · 2021Review
- A preoperative standardized feeding protocol improves human milk use in infants with complex congenital heart disease.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundHuman milk reduces morbidities in extremely low birth weight (ELBW) infants. However, clinical instability often precludes ELBW infants from receiving early enteral feeds. This study compared clinical outcomes before and after implementing an oropharyngeal colostrum (COL) protocol in a cohort of inborn (born at our facility) ELBW infants. STUDY
designThis is a retrospective cohort study of inborn ELBW infants admitted to the Duke Intensive Care Nursery from January 2007 to September 2011. In November 2010, we initiated a COL protocol for infants not enterally fed whose mothers were providing breastmilk. Infants received 0.1 mL of fresh COL to each cheek every 4 hours for 5 days beginning in the first 48 postnatal hours. We assessed demographics, diagnoses, feeding history, and mortality and for the presence of medical necrotizing enterocolitis (NEC), surgical NEC, and spontaneous perforation. Between-group comparisons were made using Fisher's exact test or Wilcoxon rank sum testing where appropriate.
resultsOf the 369 infants included, 280 (76%) were born prior to the COL protocol (Pre-COL Cohort [PCC]), and 89 (24%) were born after (COL Cohort [CC]). Mortality and the percentage of infants with surgical NEC and spontaneous perforations were statistically similar between the groups. The CC weighed an average (interquartile range) of 1,666 (1,399, 1,940) g at 36 weeks versus 1,380 (1,190, 1,650) g for the PCC (p<0.001). In a multivariable analysis with birth weight as a covariable, weight at 36 weeks was significantly greater (37 g; p<0.01).
conclusionsInitiating oropharyngeal COL in ELBW infants in the first 2 postnatal days appears feasible and safe and may be nutritionally beneficial. Further research is needed to determine if early COL administration reduces neonatal morbidity and mortality.
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