ArticleBMC genomics2013
Genetic variability of mutans streptococci revealed by wide whole-genome sequencing.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Characterization of plasmalogen production in facultative anaerobic bacteria and aerobic synthesis in recombinantApplied and environmental microbiology · 2026Article
- ProGenFixer: An Ultrafast and Accurate Tool for Correcting Prokaryotic Genome Sequences Using a Mapping-Free Algorithm.Computational and structural biotechnology journal · 2026Article
- The Outer Surface Protease, SepM, Is Required forJournal of bacteriology · 2022Article
- Investigating CRISPR spacer targets and their impact on genomic diversification ofFrontiers in genetics · 2022Article
- A Novel Competence Pathway in the Oral PathogenJournal of dental research · 2021Article
- Article
- Inhibition ofBiotechnology reports (Amsterdam, Netherlands) · 2019Article
- Conserved Pheromone Production, Response and Degradation byFrontiers in microbiology · 2019Article
- CovR and VicRKX Regulate Transcription of the Collagen Binding Protein Cnm of Streptococcus mutans.Journal of bacteriology · 2018Article
- Transmission patterns of Streptococcus mutans demonstrated by a combined rep-PCR and MLST approach.Clinical oral investigations · 2018Article
- Complete Genome Sequences of Streptococcus sobrinus SL1 (ATCC 33478 = DSM 20742), NIDR 6715-7 (ATCC 27351), NIDR 6715-15 (ATCC 27352), and NCTC 10919 (ATCC 33402).Microbiology resource announcements · 2018Article
- Whole genome sequence and phenotypic characterization of a CbmMolecular oral microbiology · 2018Article
- PGAP-X: extension on pan-genome analysis pipeline.BMC genomics · 2018Article
- Hidden Gems in the Transcriptome Maps of Competent Streptococci.Frontiers in molecular biosciences · 2018Article
- Exploring the Genomic Diversity and Cariogenic Differences of Streptococcus mutans Strains Through Pan-Genome and Comparative Genome Analysis.Current microbiology · 2017Article
- Collagen-binding proteins of Streptococcus mutans and related streptococci.Molecular oral microbiology · 2017Review
- SepM, a Streptococcal Protease Involved in Quorum Sensing, Displays Strict Substrate Specificity.Journal of bacteriology · 2016Article
- Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.Journal of oral microbiology · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMutans streptococci are a group of bacteria significantly contributing to tooth decay. Their genetic variability is however still not well understood.
resultsGenomes of 6 clinical S. mutans isolates of different origins, one isolate of S. sobrinus (DSM 20742) and one isolate of S. ratti (DSM 20564) were sequenced and comparatively analyzed. Genome alignment revealed a mosaic-like structure of genome arrangement. Genes related to pathogenicity are found to have high variations among the strains, whereas genes for oxidative stress resistance are well conserved, indicating the importance of this trait in the dental biofilm community. Analysis of genome-scale metabolic networks revealed significant differences in 42 pathways. A striking dissimilarity is the unique presence of two lactate oxidases in S. sobrinus DSM 20742, probably indicating an unusual capability of this strain in producing H2O2 and expanding its ecological niche. In addition, lactate oxidases may form with other enzymes a novel energetic pathway in S. sobrinus DSM 20742 that can remedy its deficiency in citrate utilization pathway.Using 67 S. mutans genomes currently available including the strains sequenced in this study, we estimates the theoretical core genome size of S. mutans, and performed modeling of S. mutans pan-genome by applying different fitting models. An "open" pan-genome was inferred.
conclusionsThe comparative genome analyses revealed diversities in the mutans streptococci group, especially with respect to the virulence related genes and metabolic pathways. The results are helpful for better understanding the evolution and adaptive mechanisms of these oral pathogen microorganisms and for combating them.
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