ArticleAdipocyte2013
Heart hormones fueling a fire in fat.
Article in Adipocyte, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.Diabetes · 2021Article
- Localization profiles of natriuretic peptides in hearts of pre-hibernating and hibernating Anatolian ground squirrels (Spermophilus xanthoprymnus).Veterinary research communications · 2019Article
- Cardiac natriuretic peptides promote adipose 'browning' through mTOR complex-1.Molecular metabolism · 2018Article
- Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes.Scientific reports · 2018Article
- Distinct roles of TRAF6 and TAK1 in the regulation of adipocyte survival, thermogenesis program, and high-fat diet-induced obesity.Oncotarget · 2017Article
- Multiphasic Regulation of Systemic and Peripheral Organ Metabolic Responses to Cardiac Hypertrophy.Circulation. Heart failure · 2017Article
- White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.Scientific reports · 2017Article
- Functional and anatomical characterization of brown adipose tissue in heart failure with blood oxygen level dependent magnetic resonance.NMR in biomedicine · 2016Article
- Review
- Increased Hydration Can Be Associated with Weight Loss.Frontiers in nutrition · 2016Review
- Renaissance of brown adipose tissue research: integrating the old and new.International journal of obesity supplements · 2015Review
- Neural innervation of white adipose tissue and the control of lipolysis.Frontiers in neuroendocrinology · 2014Review
- Characterization of adipocyte stress response pathways during hibernation in thirteen-lined ground squirrels.Molecular and cellular biochemistry · 2014Article
- Syndecan-1 is required to maintain intradermal fat and prevent cold stress.PLoS genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our view of how adipose tissue metabolism is regulated recently experienced a change in focus and breadth, meaning that some of the key controlling factors were not fully in the picture. The catecholamines of the sympathetic nervous system are well-known activators of β-adrenergic receptors in adipocytes to increase lipolysis. They also drive energy expenditure in brown adipose tissue and, importantly, the "browning" of cells in white adipose depots. However, this is clearly not the whole story. In earlier work, we established a pathway from β-adrenergic receptors to p38 MAP kinase to drive the transcription of brown adipocyte genes and respiratory uncoupling. Now we recently discovered that cardiac natriuretic peptides (NPs) stimulate a similar "browning" of human and mouse adipocytes. NPs activate the guanylyl cyclase coupled NP receptor A and activation of protein kinase G. Importantly, this pathway also depends upon p38 MAPK. These two pathways work together, additively increasing expression of brown adipocyte marker genes, as well as reflexively controlling each other's components. We discuss these findings and how the control of body fat by these cardiac hormones, in conjunction with the sympathetic nervous system, has implications for obesity as well as cardiovascular disease, including hypertension and heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.