ArticleJournal of interventional gastroenterology2012
Indigocarmine added to the water exchange method enhances adenoma detection - a RCT.
Article in Journal of interventional gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial (RCT) to Compare Adenoma Detection Rate of Combined Chromoendoscopy (Indigo Carmine) With Water Infusion in Lieu of Air Insufflation (Water Method) vs. Water Method Alone in Screening Colonoscopy
Comparative Efficacy of Water & Indigo Carmine vs Water or Air Method
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chromoscopy versus conventional endoscopy for the detection of polyps in the colon and rectum.The Cochrane database of systematic reviews · 2016Pooled it
- A prospective RCT comparing combined chromoendoscopy with water exchange (CWE) vs water exchange (WE) vs air insufflation (AI) in adenoma detection in screening colonoscopy.United European gastroenterology journal · 2019Trial
- Diagnostic and therapeutic applications of water-immersion colonoscopy.World journal of gastroenterology · 2015Review
- Endoscopic innovations to increase the adenoma detection rate during colonoscopy.World journal of gastroenterology · 2014Review
- Impact of water exchange colonoscopy on serum sodium and potassium levels: an observational study.Digestive diseases and sciences · 2014Observational
- Chromocolonoscopy for colorectal cancer screening: Dive into the Big Blue.Journal of interventional gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChromoendoscopy with dye spray and the water method both increase adenoma detection. HYPOTHESIS: Adding indigocarmine to the water method will enhance further the effectiveness of the latter in adenoma detection.
methodsScreening colonoscopy was performed with the water method (control) or with 0.008% indigocarmine added (study) by two endoscopists. Randomization was based on computer-generated codes contained in blocks of pre-arranged opaque sealed envelopes. High resolution colonoscopes were used. Upon insertion into the rectum, air was suctioned. With the air pump turned off, water was infused using a blunt needle adaptor connected to the scope channel and a foot pump to facilitate scope insertion until the cecum was reached. Residual stool causing cloudiness was suctioned followed by infusion of clear or colored water (water exchange) to facilitate scope passage with minimal distention of the colonic lumen. Upon seeing the appendix opening under water, water was suctioned and air was insufflated to facilitate inspection on scope withdrawal. STATISTICS: Sample size calculation revealed 168 patients (84/group) needed to be randomized. Study was IRB-approved and registered (NCT01383265).
resultsThere were no significant differences in mean age, gender distribution, BMI, and family history of colon cancer. Cecal intubation success rate was 100% in both groups. The overall adenoma detection rate was 44% (water only) versus 62% (water with indigocarmine), respectively (p=0.03). One cancer was detected in each group.
conclusionIn a RCT, indigocarmine at 0.008% concentration, added to the water method, significantly enhanced further the effectiveness of the latter in detecting adenomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.