ArticlePloS one2013
From Chemistry to Behavior. Molecular Structure and Bioactivity of Repellents against Ixodes ricinus Ticks.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Repellent Activity of the Botanical Compounds Thymol, Carvacrol, Nootkatone, and Eugenol AgainstPathogens (Basel, Switzerland) · 2025Article
- Sensing of Volatile Organic Compounds by Haller's Structure in Ixodidae Tick: Electroscutumography and Olfactometric Bioassay.Biosensors · 2025Article
- Repellent Activity of DEET Combined with Botanical Compounds AgainstPathogens (Basel, Switzerland) · 2025Article
- Ecological Repellent Preparations Based on Natural Polymers with the Addition of Essential Oils Acting on Ticks.Insects · 2024Article
- Comparative analysis of essential oil efficacy against the Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae).Parasites, hosts and diseases · 2024Article
- The Behavior ofLife (Basel, Switzerland) · 2023Article
- Behavioral Repertoire on a Vertical Rod-An Ethogram inLife (Basel, Switzerland) · 2022Article
- Persistence Enhancement of a Promising Tick Repellent, Benzyl Isothiocyanate, by Yeast Microcarriers.Molecules (Basel, Switzerland) · 2021Article
- Acaricidal and Repellent Effects of Essential Oils against Ticks: A Review.Pathogens (Basel, Switzerland) · 2021Review
- Chemosensory and Behavioural Responses ofInsects · 2020Article
- Essential oils as tick repellents on clothing.Experimental & applied acarology · 2019Article
- Behavioral responses of Ixodes scapularis tick to natural products: development of novel repellents.Experimental & applied acarology · 2019Article
- Repellency Effect of Essential Oils of some Native Plants and Synthetic Repellents against Human Flea,Journal of arthropod-borne diseases · 2017Article
Corrections and comments
- Erratum issuedFabbro, Simone Del [corrected to Del Fabbro, Simone]
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tick-borne zoonoses are considered as emerging diseases. Tick repellents represent an effective tool for reducing the risk of tick bite and pathogens transmission. Previous work demonstrated the repellent activity of the phenylpropanoid eugenol against Ixodes ricinus; here we investigate the relationship between molecular structure and repellency in a group of substances related to that compound. We report the biological activity of 18 compounds varying for the presence/number of several moieties, including hydroxyl and methoxy groups and carbon side-chain. Each compound was tested at different doses with a bioassay designed to measure repellency against individual tick nymphs. Both vapor pressure and chemical features of the tested compounds appeared to be related to repellency. In particular, the hydroxyl and methoxy groups as well as the side-chain on the benzene ring seem to play a role. These results are discussed in light of available data on chemical perception in ticks. In the course of the study new repellent compounds were identified; the biological activity of some of them (at least as effective as the "gold standard" repellent DEET) appears to be very promising from a practical point of view.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.