ArticlePloS one2013
Biochemical Characteristics and PrP(Sc) Distribution Pattern in the Brains of Cattle Experimentally Challenged with H-type and L-type Atypical BSE.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 15 citations in OpenAlex.
- Bovine Spongiform Encephalopathy: An Integrated Review of Prion Mechanisms, Neuroanatomy, and Control.Veterinary sciences · 2026Review
- Article
- Conventional and State-of-the-Art Detection Methods of Bovine Spongiform Encephalopathy (BSE).International journal of molecular sciences · 2023Review
- The First Evaluation of Proteinase K-Resistant Prion Protein (PrPMedicina (Kaunas, Lithuania) · 2022Article
- Influence of Interspecies Transmission of Atypical Bovine Spongiform Encephalopathy Prions to Hamsters on Prion Characteristics.Frontiers in veterinary science · 2020Article
- Bovine Spongiform Encephalopathy - A Review from the Perspective of Food Safety.Food safety (Tokyo, Japan) · 2019Review
- Deciphering the BSE-type specific cell and tissue tropisms of atypical (H and L) and classical BSE.Prion · 2019Article
- Article
- Article
- Atypical BSE: Current Knowledge and Knowledge Gaps.Food safety (Tokyo, Japan) · 2017Review
- Oral Transmission of L-Type Bovine Spongiform Encephalopathy Agent among Cattle.Emerging infectious diseases · 2017Article
- Spontaneous diseases in captive ratites (Struthioniformes) in northwestern Germany: A retrospective study.PloS one · 2017Article
- Intra- and Interspecies Transmission of Atypical BSE - What Can We Learn from It?Food safety (Tokyo, Japan) · 2016Review
- Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE.Scientific reports · 2016Article
- Whole Blood Gene Expression Profiling in Preclinical and Clinical Cattle Infected with Atypical Bovine Spongiform Encephalopathy.PloS one · 2016Article
- The pathological and molecular but not clinical phenotypes are maintained after second passage of experimental atypical bovine spongiform encephalopathy in cattle.BMC veterinary research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides the classical form of bovine spongiform encephalopathy (BSE) that has been known for almost three decades, two atypical forms designated H-type and L-type BSE have recently been described. While the main diagnostic feature of these forms is the altered biochemical profile of the accumulated PrP(Sc), it was also observed in the initial analysis that L-type BSE displays a distribution pattern of the pathological prion protein (PrP(Sc)), which clearly differs from that observed in classical BSE (C-type). Most importantly, the obex region in the brainstem is not the region with the highest PrP(Sc) concentrations, but PrP(Sc) is spread more evenly throughout the entire brain. A similar distribution pattern has been revealed for H-type BSE by rapid test analysis. Based on these findings, we performed a more detailed Western blot study of the anatomical PrP(Sc) distribution pattern and the biochemical characteristics (molecular mass, glycoprofile as well as PK sensitivity) in ten different anatomical locations of the brain from cattle experimentally challenged with H- or L-type BSE, as compared to cattle challenged with C-type BSE. Results of this study revealed distinct differences in the PrP(Sc) deposition patterns between all three BSE forms, while the biochemical characteristics remained stable for each BSE type among all analysed brain areas.
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