ArticlePloS one2013
Secretome Analysis of the Pine Wood Nematode Bursaphelenchus xylophilus Reveals the Tangled Roots of Parasitism and Its Potential for Molecular Mimicry.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 124 citations in OpenAlex.
- A neprilysin effector from the pinewood nematode Bursaphelenchus xylophilus targets pine caffeic acid O-methyltransferase and inhibits lignin biosynthesis.Pest management science · 2026Article
- Exosome-mediated delivery of microRNAs by root-knot nematodes.PLoS pathogens · 2026Article
- A trehalase-derived MAMP triggers LecRK-V-mediated immune responses inScience advances · 2025Article
- Analysis of the sulfate permease family inFrontiers in plant science · 2025Article
- Detection Methods for Pine Wilt Disease: A Comprehensive Review.Plants (Basel, Switzerland) · 2024Review
- Whole-Genome Sequences of 13 Chinese Indigenous Pinewood Nematodes,International journal of molecular sciences · 2024Article
- Biocontrol potential of endophytic fungi against phytopathogenic nematodes on potato (Solanum tuberosum L.).Scientific reports · 2024Article
- Evolution of parasitism genes in the plant parasitic nematodes.Scientific reports · 2024Article
- Pine wilt disease: what do we know from proteomics?BMC plant biology · 2024Review
- Transcriptomic response of Pinus massoniana to infection stress from the pine wood nematode Bursaphelenchus xylophilus.Stress biology · 2023Article
- In silico secretome analyses of the polyphagous root-knot nematode Meloidogyne javanica: a resource for studying M. javanica secreted proteins.BMC genomics · 2023Article
- Two strainsBiodiversity data journal · 2023Article
- Identification of the Extracellular Nuclease Influencing Soaking RNA Interference Efficiency inInternational journal of molecular sciences · 2022Article
- Molecular Defense Response of Pine Trees (Cells · 2022Review
- Roles of Species-Specific Legumains in Pathogenicity of the Pinewood NematodeInternational journal of molecular sciences · 2022Article
- Article
- Genes Encoding Potential Molecular Mimicry Proteins as the Specific Targets for DetectingFrontiers in plant science · 2022Article
- Novel Functional Analysis for Pathogenic Proteins ofFrontiers in plant science · 2022Article
- A new strain of Volutella citrinella with nematode predation and nematicidal activity, isolated from the cysts of potato cyst nematodes in China.BMC microbiology · 2021Article
- Mining nematode protein secretomes to explain lifestyle and host specificity.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since it was first introduced into Asia from North America in the early 20(th) century, the pine wood nematode Bursaphelenchus xylophilus has caused the devastating forest disease called pine wilt. The emerging pathogen spread to parts of Europe and has since been found as the causal agent of pine wilt disease in Portugal and Spain. In 2011, the entire genome sequence of B. xylophilus was determined, and it allowed us to perform a more detailed analysis of B. xylophilus parasitism. Here, we identified 1,515 proteins secreted by B. xylophilus using a highly sensitive proteomics method combined with the available genomic sequence. The catalogue of secreted proteins contained proteins involved in nutrient uptake, migration, and evasion from host defenses. A comparative functional analysis of the secretome profiles among parasitic nematodes revealed a marked expansion of secreted peptidases and peptidase inhibitors in B. xylophilus via gene duplication and horizontal gene transfer from fungi and bacteria. Furthermore, we showed that B. xylophilus secreted the potential host mimicry proteins that closely resemble the host pine's proteins. These proteins could have been acquired by host-parasite co-evolution and might mimic the host defense systems in susceptible pine trees during infection. This study contributes to an understanding of their unique parasitism and its tangled roots, and provides new perspectives on the evolution of plant parasitism among nematodes.
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