ArticlePloS one2013
A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Compressed variance component mixed model reveals epistasis associated with flowering inFrontiers in plant science · 2023Article
- Overview of frequent pattern mining.Genomics & informatics · 2022Article
- The Enigmatic Etiology of Oculo-Auriculo-Vertebral Spectrum (OAVS): An Exploratory Gene Variant Interaction Approach in Candidate Genes.Life (Basel, Switzerland) · 2022Article
- Associating complex traits with genetic variants: polygenic risk scores, pleiotropy and endophenotypes.Genetica · 2022Article
- Identification of the associations between genes and quantitative traits using entropy-based kernel density estimation.Genomics & informatics · 2022Article
- Machine Learning to Identify Interaction of Single-Nucleotide Polymorphisms as a Risk Factor for Chronic Drug-Induced Liver Injury.International journal of environmental research and public health · 2021Article
- Spatial rank-based multifactor dimensionality reduction to detect gene-gene interactions for multivariate phenotypes.BMC bioinformatics · 2021Article
- Effect of interaction between obesity-promoting genetic variants and behavioral factors on the risk of obese phenotypes.Molecular genetics and genomics : MGG · 2021Article
- Investigation of gene-gene interactions of clock genes for chronotype in a healthy Korean population.Genomics & informatics · 2020Article
- A new efficient method to detect genetic interactions for lung cancer GWAS.BMC medical genomics · 2020Article
- A parallelized strategy for epistasis analysis based on Empirical Bayesian Elastic Net models.Bioinformatics (Oxford, England) · 2020Article
- Brain Imaging Genomics: Integrated Analysis and Machine Learning.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2020Article
- Gene-Gene Interaction Analysis for the Survival Phenotype Based on the Kaplan-Meier Median Estimate.BioMed research international · 2020Article
- Embracing study heterogeneity for finding genetic interactions in large-scale research consortia.Genetic epidemiology · 2020Article
- AreJournal of sports science & medicine · 2019Article
- Non-additive effects of ACVR2A in preeclampsia in a Philippine population.BMC pregnancy and childbirth · 2019Article
- Detecting gene-gene interactions for complex quantitative traits using generalized fuzzy classification.BMC bioinformatics · 2018Article
- Polygenic Study of Endurance-Associated Genetic MarkersJournal of human kinetics · 2018Article
- Fuzzy set-based generalized multifactor dimensionality reduction analysis of gene-gene interactions.BMC medical genomics · 2018Article
- Individual Responsiveness to Exercise-Induced Fat Loss and Improvement of Metabolic Profile in Young Women is Associated with Polymorphisms of Adrenergic Receptor Genes.Journal of sports science & medicine · 2018Article
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Authors and funding
10 authors.
Funding
Abstract
We present an extension of the two-class multifactor dimensionality reduction (MDR) algorithm that enables detection and characterization of epistatic SNP-SNP interactions in the context of a quantitative trait. The proposed Quantitative MDR (QMDR) method handles continuous data by modifying MDR's constructive induction algorithm to use a T-test. QMDR replaces the balanced accuracy metric with a T-test statistic as the score to determine the best interaction model. We used a simulation to identify the empirical distribution of QMDR's testing score. We then applied QMDR to genetic data from the ongoing prospective Prevention of Renal and Vascular End-Stage Disease (PREVEND) study.
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