ArticleFrontiers in genetics2013
Extracellular circulating viral microRNAs: current knowledge and perspectives.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Exosomal nanocarriers of immune fate: molecular insights into cancer immunity, pathogen defense, and emerging immunotherapies.Clinical and experimental immunology · 2026Review
- Porphyromonas gingivalis infection of oral keratinocytes drives the release of pro-inflammatory extracellular vesicles.Scientific reports · 2025Article
- MicroRNA of N-region from SARS-CoV-2: Potential sensing components for biosensor development.Biotechnology and applied biochemistry · 2022Article
- Mechanisms of Immunothrombosis by SARS-CoV-2.Biomolecules · 2021Review
- Extracellular vesicles in the context of Mycobacterium tuberculosis infection.Molecular immunology · 2021Review
- Serum Exosomal microRNA Profiling in AIDS Complicated withInfection and drug resistance · 2021Article
- Human Cytomegalovirus-Encoded microRNAs Can Be Found in Saliva Samples from Renal Transplant Recipients.Non-coding RNA · 2020Article
- Circulating Epstein-Barr virus microRNA profile reveals novel biomarker for nasopharyngeal carcinoma diagnosis.Cancer biomarkers : section A of Disease markers · 2020Article
- Extracellular RNA in viral-host interactions: Thinking outside the cell.Wiley interdisciplinary reviews. RNA · 2019Review
- Exosomes in Pathogen Infections: A Bridge to Deliver Molecules and Link Functions.Frontiers in immunology · 2018Review
- Exosomes from uninfected cells activate transcription of latent HIV-1.The Journal of biological chemistry · 2017Article
- Exosomes in Viral Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems.International journal of molecular sciences · 2016Review
- Review
- Extracellular vesicles from infected cells: potential for direct pathogenesis.Frontiers in microbiology · 2015Review
- Viral miRNAs in plasma and urine divulge JC polyomavirus infection.Virology journal · 2014Article
- The origin, function and diagnostic potential of extracellular microRNA in human body fluids.Frontiers in genetics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs responsible of post-transcriptional regulation of gene expression through interaction with messenger RNAs (mRNAs). They are involved in important biological processes and are often dysregulated in a variety of diseases, including cancer and infections. Viruses also encode their own sets of miRNAs, which they use to control the expression of either the host's genes and/or their own. In the past few years evidence of the presence of cellular miRNAs in extracellular human body fluids such as serum, plasma, saliva, and urine has accumulated. They have been found either cofractionate with the Argonaute2 protein or in membrane-bound vesicles such as exosomes. Although little is known about the role of circulating miRNAs, it has been demonstrated that miRNAs secreted by virus-infected cells are transferred to and act in uninfected recipient cells. In this work we summarize the current knowledge on viral circulating miRNAs and provide a few examples of computational prediction of their function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.