ArticleFrontiers in immunology2013
Weft, warp, and weave: the intricate tapestry of calcium channels regulating T lymphocyte function.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Distinct Gene Expression Patterns of Calcium Channels and Related Signaling Pathways Discovered in Lymphomas.Frontiers in pharmacology · 2022Article
- Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.Frontiers in immunology · 2019Article
- Article
- Effects of α-conotoxin ImI on TNF-α, IL-8 and TGF-β expression by human macrophage-like cells derived from THP-1 pre-monocytic leukemic cells.Scientific reports · 2017Article
- Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells.Frontiers in immunology · 2017Article
- Article
- An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies.Lab on a chip · 2015Article
- Signature Channels of Excitability no More: L-Type Channels in Immune Cells.Frontiers in immunology · 2015Review
- Tweeters, Woofers and Horns: The Complex Orchestration of Calcium Currents in T Lymphocytes.Frontiers in immunology · 2015Review
- The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells.Nature immunology · 2014Article
- Novel immune function for the TRPV1 channel in T lymphocytes.Channels (Austin, Tex.) · 2014Article
- Barcoding T cell calcium response diversity with methods for automated and accurate analysis of cell signals (MAAACS).PLoS computational biology · 2013Article
- The regulation of calcium homeostasis in T lymphocytes.Frontiers in immunology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium (Ca(2+)) is a universal second messenger important for T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca(2+) mobilization in lymphocytes are tightly regulated and involve the coordination of diverse ion channels, membrane receptors, and signaling molecules. A mechanism termed store-operated Ca(2+) entry (SOCE), causes depletion of endoplasmic reticulum (ER) Ca(2+) stores following T cell receptor (TCR) engagement and triggers a sustained influx of extracellular Ca(2+) through Ca(2+) release-activated Ca(2+) (CRAC) channels in the plasma membrane. The ER Ca(2+) sensing molecule, stromal interaction molecule 1 (STIM1), and a pore-forming plasma membrane protein, ORAI1, have been identified as important mediators of SOCE. Here, we review the role of several additional families of Ca(2+) channels expressed on the plasma membrane of T cells that likely contribute to Ca(2+) influx following TCR engagement, particularly highlighting an important role for voltage-dependent Ca(2+) channels (CaV) in T lymphocyte biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.