ArticleFrontiers in immunology2013
Lessons to be Learned from Natural Control of HIV - Future Directions, Therapeutic, and Preventive Implications.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Trial
- Learning from nature: HIV elite controllers as blueprints for a functional cure.Virology journal · 2025Review
- Bispecific T cell engagers and their synergistic tumor immunotherapy with oncolytic viruses.American journal of cancer research · 2021Review
- Persistent HIV-controllers are more prone to spontaneously clear HCV: a retrospective cohort study.Journal of the International AIDS Society · 2020Article
- Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection.EBioMedicine · 2019Article
- Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs.Journal of virology · 2018Article
- Targeting the Latent Reservoir for HIV-1.Immunity · 2018Review
- Factors Leading to the Loss of Natural Elite Control of HIV-1 Infection.Journal of virology · 2018Article
- Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers.BMC medicine · 2018Article
- Role of APOBEC3H in the Viral Control of HIV Elite Controller Patients.International journal of medical sciences · 2018Article
- Peripheral T follicular helper Cells Make a Difference in HIV Reservoir Size between Elite Controllers and Patients on Successful cART.Scientific reports · 2017Article
- HLA-B*57 and IFNL4-related polymorphisms are associated with protection against HIV-1 disease progression in controllers.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Suppression of HIV Replication by CD8(+) Regulatory T-Cells in Elite Controllers.Frontiers in immunology · 2016Article
- Role of HLA Adaptation in HIV Evolution.Frontiers in immunology · 2015Review
- Human immunodeficiency virus vaccines.Infectious disease clinics of North America · 2014Review
- Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.AIDS research and human retroviruses · 2014Article
- Is cure of HIV infection in sight?The Indian journal of medical research · 2013Article
- The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children.Journal of virus eradicationArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating data generated from persons who naturally control HIV without the need for antiretroviral treatment has led to significant insights into the possible mechanisms of durable control of AIDS virus infection. At the center of this control is the HIV-specific CD8 T cell response, and the basis for this CD8-mediated control is gradually being revealed. Genome wide association studies coupled with HLA sequence data implicate the nature of the HLA-viral peptide interaction as the major genetic factor modulating durable control of HIV, but host genetic factors account for only around 20% of the variability in control. Other factors including specific functional characteristics of the TCR clonotypes generated in vivo, targeting of vulnerable regions of the virus that lead to fitness impairing mutations, immune exhaustion, and host restriction factors that limit HIV replication all have been shown to additionally contribute to control. Moreover, emerging data indicate that the CD8(+) T cell response may be critical for attempts to purge virus infected cells following activation of the latent reservoir, and thus lessons learned from elite controllers (ECs) are likely to impact the eradication agenda. On-going efforts are also needed to understand and address the role of immune activation in disease progression, as it becomes increasingly clear that durable immune control in ECs comes at a cost. Taken together, the research achievements in the attempt to unlock the mechanisms behind natural control of HIV will continue to be an important source of insights and ideas in the continuous search after an effective HIV vaccine, and for the attempts to achieve a sterilizing or functional cure in HIV positive patients with progressive infection.
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