ArticleFrontiers in human neuroscience2013
Repeated measurements of cerebral blood flow in the left superior temporal gyrus reveal tonic hyperactivity in patients with auditory verbal hallucinations: a possible trait marker.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- A Systematic Review and Meta-Analysis of Arterial Spin Labeling Magnetic Resonance Imaging Studies in Psychosis Spectrum Disorders.Noro psikiyatri arsivi · 2025Review
- Cerebral blood flow changes in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.European archives of psychiatry and clinical neuroscience · 2023Article
- Altered Coupling of Cerebral Blood Flow and Functional Connectivity Strength in First-Episode Schizophrenia Patients With Auditory Verbal Hallucinations.Frontiers in neuroscience · 2022Article
- Superior temporal gyrus functional connectivity predicts transcranial direct current stimulation response in Schizophrenia: A machine learning study.Frontiers in psychiatry · 2022Article
- [Cognitive control in the research domain criteria system: clinical implications for auditory verbal hallucinations].Der Nervenarzt · 2021Review
- Real-Time Functional Magnetic Resonance Imaging Neurofeedback for the Relief of Distressing Auditory-Verbal Hallucinations: Methodological and Empirical Advances.Schizophrenia bulletin · 2020Review
- Altered coupling of spontaneous brain activities and brain temperature in patients with adolescent-onset, first-episode, drug-naïve schizophrenia.Neuroradiology · 2019Article
- Real-time fMRI neurofeedback to down-regulate superior temporal gyrus activity in patients with schizophrenia and auditory hallucinations: a proof-of-concept study.Translational psychiatry · 2018Article
- Increased Striatal and Reduced Prefrontal Cerebral Blood Flow in Clinical High Risk for Psychosis.Schizophrenia bulletin · 2018Article
- Brain Tumor-Associated Psychosis and Spirituality-A Case Report.Frontiers in psychiatry · 2017Article
- Translating Neurocognitive Models of Auditory-Verbal Hallucinations into Therapy: Using Real-time fMRI-Neurofeedback to Treat Voices.Frontiers in psychiatry · 2016Article
- Subcomponents of brain T2* relaxation in schizophrenia, bipolar disorder and siblings: A Gradient Echo Plural Contrast Imaging (GEPCI) study.Schizophrenia research · 2015Article
- Auditory hallucinations: A review of the ERC "VOICE" project.World journal of psychiatry · 2015Review
- Are Auditory Hallucinations Related to the Brain's Resting State Activity? A 'Neurophenomenal Resting State Hypothesis'.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2014Review
- The role of the superior temporal lobe in auditory false perceptions: a transcranial direct current stimulation study.Neuropsychologia · 2014Article
- Future in psychopathology research.Schizophrenia bulletin · 2014Article
- rTMS in the management of auditory hallucinations in patients with schizophrenia.Shanghai archives of psychiatry · 2013Article
- Current perspectives on the mechanisms of auditory hallucinations: introduction to the special research topic.Frontiers in human neuroscience · 2013Article
- Disturbance of intentionality: a phenomenological study of body-affecting first-rank symptoms in schizophrenia.PloS one · 2013Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe left superior temporal gyrus (STG) has been suggested to play a key role in auditory verbal hallucinations (AVH) in patients with schizophrenia.
methodsEleven medicated subjects with schizophrenia and medication-resistant AVH and 19 healthy controls underwent perfusion magnetic resonance (MR) imaging with arterial spin labeling (ASL). Three additional repeated measurements were conducted in the patients. Patients underwent a treatment with transcranial magnetic stimulation (TMS) between the first 2 measurements. The main outcome measure was the pooled cerebral blood flow (CBF), which consisted of the regional CBF measurement in the left STG and the global CBF measurement in the whole brain.
resultsRegional CBF in the left STG in patients was significantly higher compared to controls (p < 0.0001) and to the global CBF in patients (p < 0.004) at baseline. Regional CBF in the left STG remained significantly increased compared to the global CBF in patients across time (p < 0.0007), and it remained increased in patients after TMS compared to the baseline CBF in controls (p < 0.0001). After TMS, PANSS (p = 0.003) and PSYRATS (p = 0.01) scores decreased significantly in patients.
conclusionsThis study demonstrated tonically increased regional CBF in the left STG in patients with schizophrenia and auditory hallucinations despite a decrease in symptoms after TMS. These findings were consistent with what has previously been termed a trait marker of AVH in schizophrenia.
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