ArticleFrontiers in cellular neuroscience2013
Layer-specific high-frequency action potential spiking in the prefrontal cortex of awake rats.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Intrinsic Dendritic Integration Features of Prefrontal Layer 5 Pyramidal Cell Subclasses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Distinctive biophysical features of human cell-types: insights from studies of neurosurgically resected brain tissue.Frontiers in synaptic neuroscience · 2023Review
- Article
- High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch.Communications biology · 2021Article
- Article
- Article
- Functional Architecture and Encoding of Tactile Sensorimotor Behavior in Rat Posterior Parietal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels.Neuron · 2018Article
- Conditional Bistability, a Generic Cellular Mnemonic Mechanism for Robust and Flexible Working Memory Computations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State.Frontiers in neural circuits · 2018Review
- Layer- and subregion-specific differences in the neurophysiological properties of rat medial prefrontal cortex pyramidal neurons.Journal of neurophysiology · 2018Article
- The stochastic nature of action potential backpropagation in apical tuft dendrites.Journal of neurophysiology · 2017Article
- D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Whole-Cell Properties of Cerebellar Nuclei Neurons In Vivo.PloS one · 2016Article
- Trace Fear Conditioning Differentially Modulates Intrinsic Excitability of Medial Prefrontal Cortex-Basolateral Complex of Amygdala Projection Neurons in Infralimbic and Prelimbic Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Juxtasomal biocytin labeling to study the structure-function relationship of individual cortical neurons.Journal of visualized experiments : JoVE · 2014Article
- Modulatory effects of inhibition on persistent activity in a cortical microcircuit model.Frontiers in neural circuits · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical pyramidal neurons show irregular in vivo action potential (AP) spiking with high-frequency bursts occurring on sparse background activity. Somatic APs can backpropagate from soma into basal and apical dendrites and locally generate dendritic calcium spikes. The critical AP frequency for generation of such dendritic calcium spikes can be very different depending on cell type or brain area involved. Previously, it was shown in vitro that calcium electrogenesis can be induced in L(ayer) 5 pyramidal neurons of prefrontal cortex (PFC). It remains an open question whether somatic burst spiking and the resulting dendritic calcium electrogenesis also occur in morphologically more compact L2/3 pyramidal neurons. Furthermore, it is not known whether critical frequencies that trigger dendritic calcium electrogenesis occur in PFC under awake conditions in vivo. Here, we addressed these issues and found that pyramidal neurons in both PFC L2/3 and L5 in awake rats spike APs in short bursts but with different probabilities. The critical frequency (CF) for calcium electrogenesis in vitro was layer-specific and lower in L5 neurons compared to L2/3. Taking the in vitro CF as a predictive measure for dendritic electrogenesis during in vivo spontaneous activity, supracritical bursts in vivo were observed in a larger fraction of L5 neurons compared to L2/3 neurons but with similar incidence within these subpopulations. Together, these results show that in PFC of awake rats, AP spiking occurs at frequencies that are relevant for dendritic calcium electrogenesis and suggest that in awake rat PFC, dendritic calcium electrogenesis may be involved in neuronal computation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.