ArticleProceedings. Biological sciences2013
Suppressors of RNAi from plant viruses are subject to episodic positive selection.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Selection profiles in RNA viruses reflect the characteristics of viruses more than individual proteins.PLoS pathogens · 2026Article
- Molecular genetic analyses of the N, NSm and NSs genes of a local population ofThe Journal of general virology · 2025Article
- Article
- Diversifying selection and climatic effects on major histocompatibility complex class II gene diversity in the greater horseshoe bat.Evolutionary applications · 2023Article
- Identification of positive and negative regulators of antiviral RNA interference in Arabidopsis thaliana.Nature communications · 2022Article
- Ecotype-specific blockage of tasiARF production by two different RNA viruses in Arabidopsis.PloS one · 2022Article
- Small but mighty: Functional landscape of the versatile geminivirus-encoded C4 protein.PLoS pathogens · 2021Review
- Positive selection and intrinsic disorder are associated with multifunctional C4(AC4) proteins and geminivirus diversification.Scientific reports · 2021Article
- Review
- Genome-Wide Variation in Potyviruses.Frontiers in plant science · 2019Article
- Piercing Fishes: Porin Expansion and Adaptation to Hematophagy in the Vampire Snail Cumia reticulata.Molecular biology and evolution · 2018Article
- Antiviral Immunity and Virus-Mediated Antagonism in Disease Vector Mosquitoes.Trends in microbiology · 2018Review
- Evolutionary features of 8K (KDa) silencing suppressor protein of Potato mop-top virus.Molecular biology research communications · 2018Article
- What Drives Positive Selection in theThe Yale journal of biology and medicine · 2016Review
- Recurrent Gene Duplication Diversifies Genome Defense Repertoire in Drosophila.Molecular biology and evolution · 2016Article
- Grapevine Pathogenic Microorganisms: Understanding Infection Strategies and Host Response Scenarios.Frontiers in plant science · 2016Review
- The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster.PLoS biology · 2015Article
- The genetics of host-virus coevolution in invertebrates.Current opinion in virology · 2014Review
- The evolution of ethylene signaling in plant chemical ecology.Journal of chemical ecology · 2014Review
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Viral suppressors of RNAi (VSRs) are proteins that actively inhibit the antiviral RNA interference (RNAi) immune response, providing an immune evasion route for viruses. It has been hypothesized that VSRs are engaged in a molecular 'arms race' with RNAi pathway genes. Two lines of evidence support this. First, VSRs from plant viruses display high sequence diversity, and are frequently gained and lost over evolutionary time scales. Second, Drosophila antiviral RNAi genes show high rates of adaptive evolution. Here, we investigate whether VSRs diversify faster than other genes and, if so, whether this is a result of positive selection, as might be expected in an arms race. By analysis of 12 plant RNA viruses, we show that the relative rate of protein evolution is higher for VSRs than for other genes, but that this is not attributable to pervasive positive selection. We argue that, because evolutionary time scales are extremely different for viruses and eukaryotes, it is improbable that viral adaptation (as measured by the ratio of non-synonymous to synonymous change) will be dominated by one-to-one coevolution with eukaryotes. Instead, for plant virus VSRs, we find strong evidence of episodic selection--diversifying selection that acts on a subset of lineages--which might be attributable to frequent shifts between different host genotypes or species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.