ArticleBioFactors (Oxford, England)
Oral administration of interferon tau enhances oxidation of energy substrates and reduces adiposity in Zucker diabetic fatty rats.
Article in BioFactors (Oxford, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Intrauterine Administration of PBMC Modulated with IFN-τ Before Embryo Transfer Improves Clinical Outcomes of IVF Patients-A Randomized Control Trial.Biomedicines · 2025Article
- Modeling approaches for assessing device-based measures of energy expenditure in school-based studies of body weight status.Frontiers in applied mathematics and statistics · 2024Article
- Parametric and Semiparametric Approaches to Analyzing Device-Based Measures of Energy Expenditure in Zucker Diabetic Fatty Rats.Frontiers in bioscience (Landmark edition) · 2023Article
- Dietary supplementation with monosodium glutamate enhances milk production by lactating sows and the growth of suckling piglets.Amino acids · 2022Article
- Dietary supplementation with branched-chain amino acids enhances milk production by lactating sows and the growth of suckling piglets.Journal of animal science and biotechnology · 2022Article
- Findings from Studies Are Congruent with Obesity Having a Viral Origin, but What about Obesity-Related NAFLD?Viruses · 2021Review
- Association of Human Plasma Metabolomics with Delayed Dark Adaptation in Age-Related Macular Degeneration.Metabolites · 2021Article
- Amino Acids in Cell Signaling: Regulation and Function.Advances in experimental medicine and biology · 2021Article
- Pharmacological Modulators of Tau Aggregation and Spreading.Brain sciences · 2020Review
- Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Article
- Chronicling the discovery of interferon tau.Reproduction (Cambridge, England) · 2017Review
- Interferon Tau Affects Mouse Intestinal Microbiota and Expression of IL-17.Mediators of inflammation · 2016Article
- Analysis of energy expenditure in diet-induced obese rats.Frontiers in bioscience (Landmark edition) · 2014Review
- Distribution of the type I interferon in different organs of chicken digestive system.Central-European journal of immunology · 2014Article
- Rapid publication-ready MS-Word tables for one-way ANOVA.SpringerPlus · 2014Article
- Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization.PloS one · 2014Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Male Zucker diabetic fatty (ZDF) rats were used to study effects of oral administration of interferon tau (IFNT) in reducing obesity. Eighteen ZDF rats (28 days of age) were assigned randomly to receive 0, 4, or 8 μg IFNT/kg body weight (BW) per day (n = 6/group) for 8 weeks. Water consumption was measured every two days. Food intake and BW were recorded weekly. Energy expenditure in 4-, 6-, 8-, and 10-week-old rats was determined using indirect calorimetry. Starting at 7 weeks of age, urinary glucose, and ketone bodies were tested daily. Rates of glucose and oleate oxidation in liver, brown adipose tissue, and abdominal adipose tissue, as well as leucine catabolism in skeletal muscle, and lipolysis in white and brown adipose tissues were greater for rats treated with 8 μg IFNT/kg BW/day in comparison with control rats. Treatment with 8 μg IFNT/kg BW/day increased heat production, reduced BW gain and adiposity, ameliorated fatty liver syndrome, delayed the onset of diabetes, and decreased concentrations of glucose, free fatty acids, triacylglycerol, cholesterol, and branched-chain amino acids in plasma, compared with control rats. Oral administration of 8 µg IFNT/kg BW/day ameliorated oxidative stress in skeletal muscle, liver, and adipose tissue, as indicated by decreased ratios of oxidized glutathione to reduced glutathione and increased concentrations of tetrahydrobiopterin. These results indicate that IFNT stimulates oxidation of energy substrates and reduces obesity in ZDF rats and may have broad important implications for preventing and treating obesity-related diseases in mammals.
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