Evidence map›Paper›PMID 23804388›Full record

ArticleJournal of clinical microbiology2013

Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility.

K Datta, P Rhee, E Byrnes, G Garcia-Effron, D S Perlin, J F Staab, K A Marr

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Manogepix demonstrates potentAntimicrobial agents and chemotherapy · 2026
    Article
  3. Article
  4. Optimizing antifungal dosing for invasiveFrontiers in pharmacology · 2025
    Article
  5. Article
  6. New Antifungal Agents with Azole Moieties.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  7. A Fatal Fungal Infection:Open forum infectious diseases · 2022
    Article
  8. Antifungal Resistance and the Role of New Therapeutic Agents.Current infectious disease reports · 2022
    Review
  9. Open forum infectious diseases · 2021
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Molecular characterisation and antifungal susceptibility of clinical Cryptococcus deuterogattii (AFLP6/VGII) isolates from Southern Brazil.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016
    Article
  15. Review
  16. Article
  17. Comparative Evaluation of the BD Phoenix Yeast ID Panel and Remel RapID Yeast Plus System for Yeast Identification.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2016
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

K DattaJohns Hopkins School of Medicine, Baltimore, Maryland, USA.
P Rhee
E Byrnes
G Garcia-Effron
D S Perlin
J F Staab
K A Marr

Funding

Mechanism of clinical resistance to echinocandin antifungal drugsR01AI069397 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI PERLIN, DAVID S · 2007 to 2011
$2.0M
Patient Oriented Research in Transplant and Oncology IDK24AI085118 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MARR, KIEREN A. · 2010 to 2014
$995k
NIAID NIH HHS AI069397NIAID NIH HHS AI85118NIAID NIH HHS K24 AI085118NIAID NIH HHS R01 AI069397
6 · The paper itself

Abstract

Isavuconazole is an extended-spectrum triazole with in vitro activity against a wide variety of fungal pathogens. Clinical isolates of molds Aspergillus lentulus and Neosartorya udagawae and yeast Cryptococcus gattii VGII (implicated in the outbreak in the Pacific Northwest, North America) exhibit reduced susceptibilities to several azoles but higher susceptibilities to isavuconazole.

Indexed as

Antifungal AgentsAspergillusAzolesCommunicable Diseases, EmergingCryptococcus gattiiHumansMicrobial Sensitivity TestsMycosesNeosartoryaNitrilesNorth AmericaPyridinesTriazolesAntifungal AgentsAzolesisavuconazoleNitrilesPyridinesTriazoles

Identifiers

PMID23804388
PMCPMC3754638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.