Evidence map›Paper›PMID 23804380›Full record

ArticleJournal of clinical microbiology2013

Algorithm-based prediction of HIV-1 subtype D coreceptor use.

Julia Dina, Stephanie Raymond, Anne Maillard, Helene Le Guillou-Guillemette, Audrey Rodalec, Agnes Beby-Defaux, Genevieve Giraudeau, Sophie Vallet, Thomas Mourez, Christopher Payan and 5 more

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Julia DinaLaboratoire de Virologie, CHU de Caen, Caen, France. Dina, dina-j@chu-caen.fr
Stephanie Raymond
Anne Maillard
Helene Le Guillou-Guillemette
Audrey Rodalec
Agnes Beby-Defaux
Genevieve Giraudeau
Sophie Vallet
Thomas Mourez
Christopher Payan
Astrid Vabret
Annick Ruffault
Virginie Ferre
Jacques Izopet
Jean-Christophe Plantier

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared the coreceptor tropism-predicting performance of a specific genotypic algorithm for HIV-1 subtype D and that of the geno2pheno algorithm with different cutoffs. The D-specific algorithm and geno2pheno with a false-positivity rate cutoff of 2.5% had the same concordance with the phenotypic determination. The geno2pheno algorithm with a false-positivity rate cutoff of 2.5%, more sensitive but slightly less specific, seems to be an appropriate alternative.

Indexed as

AlgorithmsViral TropismVirus AttachmentComputational BiologyGenotypeHIV-1HumansMolecular Sequence DataReceptors, HIVRNA, ViralSensitivity and SpecificitySequence Analysis, DNAReceptors, HIVRNA, Viral

Identifiers

PMID23804380
PMCPMC3754628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.