Evidence map›Paper›PMID 23804287›Full record

Observational studyObesity (Silver Spring, Md.)2014

Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery.

Christopher D Still, G Craig Wood, Xin Chu, Christina Manney, William Strodel, Anthony Petrick, Jon Gabrielsen, Tooraj Mirshahi, George Argyropoulos, Jamie Seiler and 3 more

Registry-linked trialOpen access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03092479 (A Randomized Trial of a Pilot Behavioral Support Intervention After Bariatric Surgery), which is not on this map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03092479 nacompletednot on this mapstarted 2017, after this paper: background citation

A Randomized Trial of a Pilot Behavioral Support Intervention After Bariatric Surgery

TypeinterventionalSponsorGeisinger ClinicRan2017 to 2017Enrolled50ConditionsObesityArmsBehavioral Intervention
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  15. Socio-Demographic and Preoperative Clinical Factors Associated With 5-Year Weight Trajectories After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024
    Article
  16. Article
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  18. Review
  19. Weight Loss Prediction after Metabolic and Bariatric Surgery.Journal of obesity & metabolic syndrome · 2023
    Review
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Christopher D StillGeisinger Obesity Research Institute, Geisinger Clinic, Danville, Pennsylvania, USA.
G Craig Wood
Xin Chu
Christina Manney
William Strodel
Anthony Petrick
Jon Gabrielsen
Tooraj Mirshahi
George Argyropoulos
Jamie Seiler
Marco Yung
Peter Benotti
Glenn S Gerhard
Geisinger Medical Center · USSt. Francis Medical Center · USPennsylvania State University · US

Funding

Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Genetic determinants of NAFLD severity and progressionR01DK091601 · NIDDK · TRANSLATIONAL GENOMICS RESEARCH INST · PI DISTEFANO, JOHANNA K, GERHARD, GLENN S · 2011 to 2015
$2.9M
Genetic Determinants of Weight Loss and Resolution of Co-MorbiditiesR01DK088231 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI GERHARD, GLENN S · 2011 to 2015
$2.5M
NIDDK NIH HHS DK072488NIDDK NIH HHS DK088231NIDDK NIH HHS DK091601NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK088231NIDDK NIH HHS R01 DK091601
6 · The paper itself

Abstract

objectiveGastric bypass surgery is an effective therapy for extreme obesity. However, substantial variability in weight loss outcomes exists that remains largely unexplained. Our objective was to determine whether any commonly collected preoperative clinical variables were associated with weight loss following Roux-en-Y gastric bypass (RYGB) surgery.

methodsThe analysis was based on a prospectively recruited observational cohort of 2,365 patients who underwent Roux-en-Y gastric bypass surgery from 2004 to 2009. Weight loss was stratified into three major phases, early (0-6 months), nadir, and long-term (>36 months). Multivariate regression models were constructed using a database of over 350 variables.

resultsA total of 12-14 preoperative variables were independently associated (P < 0.05) with each of the temporal weight loss phases. Preoperative variables associated with poorer nadir and long-term weight loss included higher baseline BMI, higher preoperative weight loss, iron deficiency, use of any diabetes medication, nonuse of bupropion medication, no history of smoking, age >50 years, and the presence of fibrosis on liver biopsy.

conclusionsSeveral variables previously associated with poorer weight loss after RYGB surgery including age, baseline BMI, and type 2 diabetes were replicated. Several others suggest possible clinical interventions for postoperative management of RYGB patients to improve weight loss outcomes.

Indexed as

Weight LossAdolescentAdultAgedAnastomosis, Roux-en-YBody Mass IndexDiabetes Mellitus, Type 2FemaleGastric BypassHumansLinear ModelsLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisObesity

Identifiers

PMID23804287
PMCPMC3819407
OpenAlexW1569663981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.